Application and clinical impact of the RESIST-4 O.K.N.V. rapid diagnostic test for carbapenemase detection in blood cultures and clinical samples

  1. Roth, Sophie
  2. Berger, Fabian K.
  3. Link, Andreas
  4. Nimmesgern, Anna
  5. Lepper, Philipp M.
  6. Murawski, Niels
  7. Bittenbring, Jörg T.
  8. Becker, Soeren ORCID logo

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1000 Titel
  • Application and clinical impact of the RESIST-4 O.K.N.V. rapid diagnostic test for carbapenemase detection in blood cultures and clinical samples
1000 Autor/in
  1. Roth, Sophie |
  2. Berger, Fabian K. |
  3. Link, Andreas |
  4. Nimmesgern, Anna |
  5. Lepper, Philipp M. |
  6. Murawski, Niels |
  7. Bittenbring, Jörg T. |
  8. Becker, Soeren |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-07
1000 Erschienen in
1000 Quellenangabe
  • 40(2):423-428
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10096-020-04021-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817559/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Invasive infections caused by carbapenemase-producing bacteria are associated with excess mortality. We applied a rapid diagnostic test (RDT) on clinical samples with an elevated likelihood of carbapenemase-producing bacteria and documented its impact on antibiotic treatment decisions. Among 38 patients, twelve tested positive for infections caused by carbapenemase-producing bacteria (31.6%), mainly in blood cultures. KPC (n = 10) was more frequent than OXA-48 (n = 2). RDT-based carbapenemase detection led to a treatment modification to ceftazidime/avibactam-containing regimens in all patients before detailed antibiotic testing results became available. Eleven patients (92%) survived the acute infection, whereas one patient with a ceftazidime/avibactam- and colistin-resistant OXA-48-positive isolate died.
1000 Sacherschließung
lokal
lokal beta-Lactamases [MeSH]
lokal Female [MeSH]
lokal Aged [MeSH]
lokal Diagnostic stewardship
lokal Humans [MeSH]
lokal Middle Aged [MeSH]
lokal Point-of-Care Testing [MeSH]
lokal Blood Culture/methods [MeSH]
lokal Enterobacteriaceae Infections/diagnosis [MeSH]
lokal Clinical microbiology
lokal Brief Report
lokal Male [MeSH]
lokal Antibiotics
lokal Bacterial Proteins [MeSH]
lokal Treatment
lokal Enterobacteriaceae/enzymology [MeSH]
lokal Diagnostic Tests, Routine/methods [MeSH]
lokal Enterobacteriaceae/isolation
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Um90aCwgU29waGll|https://frl.publisso.de/adhoc/uri/QmVyZ2VyLCBGYWJpYW4gSy4=|https://frl.publisso.de/adhoc/uri/TGluaywgQW5kcmVhcw==|https://frl.publisso.de/adhoc/uri/TmltbWVzZ2VybiwgQW5uYQ==|https://frl.publisso.de/adhoc/uri/TGVwcGVyLCBQaGlsaXBwIE0u|https://frl.publisso.de/adhoc/uri/TXVyYXdza2ksIE5pZWxz|https://frl.publisso.de/adhoc/uri/Qml0dGVuYnJpbmcsIErDtnJnIFQu|https://orcid.org/0000-0003-3634-8802
1000 Hinweis
  • DeepGreen-ID: 899c70fc963c4047b8d170a70b1130f8 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-17T14:32:16.902+0100
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1000 Zuletzt bearbeitet 2023-12-01T07:24:26.135+0100
1000 Objekt bearb. Fri Dec 01 07:24:26 CET 2023
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