Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment

  1. Singhal, Gaurav ORCID logo
  2. Morgan, Julie ORCID logo
  3. Corrigan, Frances ORCID logo
  4. Toben, Catherine ORCID logo
  5. Jawahar, Magdalene Catharine ORCID logo
  6. Jaehne, Emily ORCID logo
  7. Manavis, Jim ORCID logo
  8. Hannan, Anthony ORCID logo
  9. Baune, Bernhard T ORCID logo

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1000 Titel
  • Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment
1000 Autor/in
  1. Singhal, Gaurav |
  2. Morgan, Julie |
  3. Corrigan, Frances |
  4. Toben, Catherine |
  5. Jawahar, Magdalene Catharine |
  6. Jaehne, Emily |
  7. Manavis, Jim |
  8. Hannan, Anthony |
  9. Baune, Bernhard T |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-05-25
1000 Erschienen in
1000 Quellenangabe
  • 41(3):469-486
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10571-020-00862-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920895/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, PE, EE, or PE + EE groups and provided with either no treatment, a running wheel, a variety of plastic and wooden objects alone or in combination with a running wheel for seven weeks, respectively. Immunohistochemistry and 8-color flow cytometry were used to determine the numbers of dentate gyrus glial cells, and the proportions of CD4
1000 Sacherschließung
lokal Mice, Inbred C57BL [MeSH]
lokal T-Lymphocytes/immunology [MeSH]
lokal Environmental enrichment
lokal Lymph Nodes/cytology [MeSH]
lokal Microfilament Proteins/metabolism [MeSH]
lokal Microglia
lokal Glial Fibrillary Acidic Protein/metabolism [MeSH]
lokal Brain/cytology [MeSH]
lokal Astrocytes
lokal Dentate Gyrus/metabolism [MeSH]
lokal Animals [MeSH]
lokal Astrocytes/cytology [MeSH]
lokal Aging
lokal Immunophenotyping [MeSH]
lokal Cervical Vertebrae/cytology [MeSH]
lokal Biomarkers/metabolism [MeSH]
lokal Neuroglia/cytology [MeSH]
lokal Physical exercise
lokal Calcium-Binding Proteins/metabolism [MeSH]
lokal Original Research
lokal Environment [MeSH]
lokal Physical Conditioning, Animal [MeSH]
lokal T cells
lokal Antigens, CD/metabolism [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-9460-0159|https://orcid.org/0000-0001-8245-218X|https://orcid.org/0000-0001-6150-8893|https://orcid.org/0000-0001-8399-4108|https://orcid.org/0000-0001-7136-1848|https://orcid.org/0000-0003-0532-1623|https://orcid.org/0000-0001-7381-7781|https://orcid.org/0000-0001-7532-8922|https://orcid.org/0000-0001-6548-426X
1000 Hinweis
  • DeepGreen-ID: 80d01b03b8b74d9f8278cbad2bf59b21 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-17T15:15:10.393+0100
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