Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study

  1. Limperger, Verena ORCID logo
  2. Kenet, Gili
  3. Kiesau, Bettina
  4. Köther, Max
  5. Schmeiser, Malin
  6. Langer, Florian
  7. Juhl, David
  8. Shneyder, Maria
  9. Franke, Andre
  10. Klostermeier, Ulrich K.
  11. Mesters, Rolf
  12. Rühle, Frank
  13. Stoll, Monika
  14. Steppat, Dagmar
  15. Kowalski, Dorothee
  16. Rocke, Angela
  17. Kuta, Piotr
  18. Bajorat, Tido
  19. Torge, Antje
  20. Neuner, Bruno
  21. Junker, Ralf
  22. Nowak-Göttl, Ulrike

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1000 Titel
  • Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study
1000 Autor/in
  1. Limperger, Verena |
  2. Kenet, Gili |
  3. Kiesau, Bettina |
  4. Köther, Max |
  5. Schmeiser, Malin |
  6. Langer, Florian |
  7. Juhl, David |
  8. Shneyder, Maria |
  9. Franke, Andre |
  10. Klostermeier, Ulrich K. |
  11. Mesters, Rolf |
  12. Rühle, Frank |
  13. Stoll, Monika |
  14. Steppat, Dagmar |
  15. Kowalski, Dorothee |
  16. Rocke, Angela |
  17. Kuta, Piotr |
  18. Bajorat, Tido |
  19. Torge, Antje |
  20. Neuner, Bruno |
  21. Junker, Ralf |
  22. Nowak-Göttl, Ulrike |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-27
1000 Erschienen in
1000 Quellenangabe
  • 51(2):494-501
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11239-020-02169-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886710/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG 'non-O' was significantly more often diagnosed in patients compared to BG 'O' (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.
1000 Sacherschließung
lokal Genetic Predisposition to Disease [MeSH]
lokal Prothrombin/genetics [MeSH]
lokal Female [MeSH]
lokal Prothrombin 19911 A>G polymorphism
lokal Recurrence
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Adult [MeSH]
lokal Male gender
lokal Humans [MeSH]
lokal Thrombosis
lokal Venous Thromboembolism/genetics [MeSH]
lokal Venous Thromboembolism/etiology [MeSH]
lokal Middle Aged [MeSH]
lokal Risk Factors [MeSH]
lokal Blood Group Antigens/blood [MeSH]
lokal Venous Thromboembolism/blood [MeSH]
lokal Germany/epidemiology [MeSH]
lokal Article
lokal Male [MeSH]
lokal Young Adult [MeSH]
lokal Sex Factors [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4138-0161|https://frl.publisso.de/adhoc/uri/S2VuZXQsIEdpbGk=|https://frl.publisso.de/adhoc/uri/S2llc2F1LCBCZXR0aW5h|https://frl.publisso.de/adhoc/uri/S8O2dGhlciwgTWF4|https://frl.publisso.de/adhoc/uri/U2NobWVpc2VyLCBNYWxpbg==|https://frl.publisso.de/adhoc/uri/TGFuZ2VyLCBGbG9yaWFu|https://frl.publisso.de/adhoc/uri/SnVobCwgRGF2aWQ=|https://frl.publisso.de/adhoc/uri/U2huZXlkZXIsIE1hcmlh|https://frl.publisso.de/adhoc/uri/RnJhbmtlLCBBbmRyZQ==|https://frl.publisso.de/adhoc/uri/S2xvc3Rlcm1laWVyLCBVbHJpY2ggSy4=|https://frl.publisso.de/adhoc/uri/TWVzdGVycywgUm9sZg==|https://frl.publisso.de/adhoc/uri/UsO8aGxlLCBGcmFuaw==|https://frl.publisso.de/adhoc/uri/U3RvbGwsIE1vbmlrYQ==|https://frl.publisso.de/adhoc/uri/U3RlcHBhdCwgRGFnbWFy|https://frl.publisso.de/adhoc/uri/S293YWxza2ksIERvcm90aGVl|https://frl.publisso.de/adhoc/uri/Um9ja2UsIEFuZ2VsYQ==|https://frl.publisso.de/adhoc/uri/S3V0YSwgUGlvdHI=|https://frl.publisso.de/adhoc/uri/QmFqb3JhdCwgVGlkbw==|https://frl.publisso.de/adhoc/uri/VG9yZ2UsIEFudGpl|https://frl.publisso.de/adhoc/uri/TmV1bmVyLCBCcnVubw==|https://frl.publisso.de/adhoc/uri/SnVua2VyLCBSYWxm|https://frl.publisso.de/adhoc/uri/Tm93YWstR8O2dHRsLCBVbHJpa2U=
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1000 Erstellt am 2023-11-17T17:19:57.252+0100
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