Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now

  1. Zimmermann, Herbert ORCID logo

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1000 Titel
  • Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now
1000 Autor/in
  1. Zimmermann, Herbert |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-17
1000 Erschienen in
1000 Quellenangabe
  • 17(1):117-125
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11302-020-09755-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954995/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of intercellular communication, signaling via nucleotides. The signaling cascades involved in purinergic signaling include intracellular storage of nucleotides, nucleotide release, extracellular hydrolysis, and the effect of the released compounds or their hydrolysis products on target tissues via specific receptor systems. In this context ectonucleotidases play several roles. They inactivate released and physiologically active nucleotides, produce physiologically active hydrolysis products, and facilitate nucleoside recycling. This review briefly highlights the development of our knowledge of two types of enzymes involved in extracellular nucleotide hydrolysis and thus purinergic signaling, the ectonucleoside triphosphate diphosphohydrolases, and ecto-5'-nucleotidase.
1000 Sacherschließung
lokal 5'-Nucleotidase/metabolism [MeSH]
lokal Humans [MeSH]
lokal Adenosine Triphosphatases/metabolism [MeSH]
lokal Review Article
lokal Adenosine/metabolism [MeSH]
lokal Receptors, Purinergic/metabolism [MeSH]
lokal Topical Collection on A Tribute to Professor Geoff Burnstock
lokal Animals [MeSH]
lokal Ecto-5′-nucleotidase
lokal Adenosine
lokal Signal Transduction/physiology [MeSH]
lokal Geoffrey Burnstock
lokal History
lokal ATP
lokal E-NTPDase
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-5944-0463
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1000 Erstellt am 2023-11-17T17:43:02.189+0100
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