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1000 Titel
  • Impact of Primary Staging with Fibroblast Activation Protein Specific Enzyme Inhibitor (FAPI)-PET/CT on Radio-Oncologic Treatment Planning of Patients with Esophageal Cancer
1000 Autor/in
  1. Ristau, J. |
  2. Giesel, F. L. |
  3. Haefner, M. F. |
  4. Staudinger, F. |
  5. Lindner, T. |
  6. Merkel, A. |
  7. Schlittenhardt, J. |
  8. Kratochwil, C. |
  9. Choyke, P. L. |
  10. Herfarth, K. |
  11. Debus, J. |
  12. Haberkorn, U. |
  13. Koerber, S. A. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-10-15
1000 Erschienen in
1000 Quellenangabe
  • 22(6):1495-1500
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s11307-020-01548-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666016/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Quinoline-based ligands targeting cancer-associated fibroblasts have emerged as promising radiopharmaceuticals in different tumor entities. The aim of this retrospective study was to explore the potential of FAPI-PET/CT in the initial staging of esophageal cancer patients and its usefulness in radiotherapy planning as a first clinical analysis.!##!Methods!#!Seven patients with treatment-naive esophageal cancer underwent FAPI-PET/CT. Tracer uptake was quantified by standardized uptake values (SUV)max and (SUV)mean. Six patients received definitive and one neoadjuvant (chemo)radiation therapy. Endo-esophageal clipping, the gold standard to define tumor margins not delineable per CT, was performed in three patients.!##!Results!#!Primary tumors demonstrated high FAPI uptake with a median SUVmax of 17.2. Excellent tumor-to-background ratios resulted in accurate target volume delineation and were found in perfect match with clipping. Detection of regional lymph node metastases facilitated the use of simultaneous integrated boost radiotherapy plans for these patients.!##!Conclusion!#!FAPI-PET/CT may be beneficial for the management of esophageal cancer particularly in planning radiotherapy, but further research is necessary to increase patient number and statistical reliability.
1000 Sacherschließung
lokal Oncological management
lokal Female [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Radiotherapy Planning, Computer-Assisted [MeSH]
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Esophageal Neoplasms/diagnostic imaging [MeSH]
lokal Positron Emission Tomography Computed Tomography [MeSH]
lokal Brief Article
lokal Middle Aged [MeSH]
lokal Esophageal Neoplasms/pathology [MeSH]
lokal Fibroblast activation protein
lokal PET
lokal Neoplasm Staging [MeSH]
lokal Enzyme Inhibitors/metabolism [MeSH]
lokal Male [MeSH]
lokal Esophageal cancer
lokal FAPI
lokal Esophageal Neoplasms/radiotherapy [MeSH]
lokal Fibroblasts/metabolism [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-17T17:45:21.800+0100
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