Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease

  1. Dafsari, Haidar ORCID logo
  2. Ray-Chaudhuri, K.
  3. Ashkan, Keyoumars
  4. Sachse, Lena
  5. Mahlstedt, Picabo
  6. Silverdale, Monty
  7. Strack, Marian
  8. Jost, Stefanie T.
  9. Reker, Paul
  10. Samuel, Michael
  11. Visser-Vandewalle, Veerle
  12. Evans, Julian
  13. Ray-Chaudhuri, Kallol
  14. Antonini, Angelo
  15. Martinez-Martin, Pablo
  16. Schrag, Anette
  17. Weintraub, Daniel
  18. Barone, Paolo
  19. Brooks, David J.
  20. Brown, Richard G.
  21. Jenner, Peter
  22. Jeon, B.
  23. Lyons, Kelly
  24. Pavese, Nicola
  25. Politis, Marios
  26. Postuma, Ronald B.
  27. Schapira, Anthony
  28. Stocchi, Fabrizio
  29. Timmermann, Lars
  30. Tsuboi, Yoshio
  31. Rizos, Alexandra
  32. Sauerbier, Anna

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1000 Titel
  • Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease
1000 Autor/in
  1. Dafsari, Haidar |
  2. Ray-Chaudhuri, K. |
  3. Ashkan, Keyoumars |
  4. Sachse, Lena |
  5. Mahlstedt, Picabo |
  6. Silverdale, Monty |
  7. Strack, Marian |
  8. Jost, Stefanie T. |
  9. Reker, Paul |
  10. Samuel, Michael |
  11. Visser-Vandewalle, Veerle |
  12. Evans, Julian |
  13. Ray-Chaudhuri, Kallol |
  14. Antonini, Angelo |
  15. Martinez-Martin, Pablo |
  16. Schrag, Anette |
  17. Weintraub, Daniel |
  18. Barone, Paolo |
  19. Brooks, David J. |
  20. Brown, Richard G. |
  21. Jenner, Peter |
  22. Jeon, B. |
  23. Lyons, Kelly |
  24. Pavese, Nicola |
  25. Politis, Marios |
  26. Postuma, Ronald B. |
  27. Schapira, Anthony |
  28. Stocchi, Fabrizio |
  29. Timmermann, Lars |
  30. Tsuboi, Yoshio |
  31. Rizos, Alexandra |
  32. Sauerbier, Anna |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-09
1000 Erschienen in
1000 Quellenangabe
  • 267(6):1830-1841
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-020-09743-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293679/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear.!##!Methods!#!In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size.!##!Results!#!Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up.!##!Conclusions!#!In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes.
1000 Sacherschließung
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Aged [MeSH]
lokal Parkinson Disease/complications [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Sleep Wake Disorders/etiology [MeSH]
lokal Parkinson’s disease sleep scale
lokal Middle Aged [MeSH]
lokal Parkinson Disease/therapy [MeSH]
lokal Sleep Wake Disorders/therapy [MeSH]
lokal Subthalamic nucleus
lokal Subthalamic Nucleus [MeSH]
lokal Quality of life
lokal Male [MeSH]
lokal Deep Brain Stimulation [MeSH]
lokal Quality of Life [MeSH]
lokal Non-motor symptoms
lokal Original Communication
lokal Outcome Assessment, Health Care [MeSH]
lokal Deep brain stimulation
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-18T00:29:42.902+0100
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