Pregnancy outcomes in interferon-beta-exposed patients with multiple sclerosis: results from the European Interferon-beta Pregnancy Registry

  1. Hellwig, Kerstin ORCID logo
  2. Geissbuehler, Yvonne
  3. Sabidó, Meritxell
  4. Popescu, Catrinel
  5. Adamo, Alessandra
  6. Klinger, Joachim
  7. Ornoy, Asher
  8. Huppke, Peter
  9. Akbaba, Metin
  10. Borghesi, Gustavo
  11. Bugge, Joerg-Peter
  12. Detering, Elke
  13. Köfüncü, Evra
  14. Luenzmann, Claudia
  15. Mueller, Bettina
  16. Olivar, Axel
  17. Suzart-Woischnik, Kiliana
  18. Wicklein, Eva-Maria
  19. Beynon, Vanessa
  20. Brown, Kate
  21. Everage, Nicholas
  22. Naylor, Maria
  23. Pandhi, Avni
  24. Ly, Anh
  25. Scheller, Silke
  26. Todorovic, Milorad
  27. Jack, Dominic
  28. Samsinger, Yvonne
  29. Weitzman, Richard

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WeightNameValue
1000 Titel
  • Pregnancy outcomes in interferon-beta-exposed patients with multiple sclerosis: results from the European Interferon-beta Pregnancy Registry
1000 Autor/in
  1. Hellwig, Kerstin |
  2. Geissbuehler, Yvonne |
  3. Sabidó, Meritxell |
  4. Popescu, Catrinel |
  5. Adamo, Alessandra |
  6. Klinger, Joachim |
  7. Ornoy, Asher |
  8. Huppke, Peter |
  9. Akbaba, Metin |
  10. Borghesi, Gustavo |
  11. Bugge, Joerg-Peter |
  12. Detering, Elke |
  13. Köfüncü, Evra |
  14. Luenzmann, Claudia |
  15. Mueller, Bettina |
  16. Olivar, Axel |
  17. Suzart-Woischnik, Kiliana |
  18. Wicklein, Eva-Maria |
  19. Beynon, Vanessa |
  20. Brown, Kate |
  21. Everage, Nicholas |
  22. Naylor, Maria |
  23. Pandhi, Avni |
  24. Ly, Anh |
  25. Scheller, Silke |
  26. Todorovic, Milorad |
  27. Jack, Dominic |
  28. Samsinger, Yvonne |
  29. Weitzman, Richard |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-26
1000 Erschienen in
1000 Quellenangabe
  • 267(6):1715-1723
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-020-09762-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293672/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Family planning is an important consideration for women with multiple sclerosis (MS), who are often diagnosed during their reproductive years. Currently, limited data are available on pregnancy outcomes in patients exposed to interferon-beta (IFN-beta) before or during pregnancy. Here, we present the cumulative pregnancy exposure data and prevalence of pregnancy and infant outcomes in IFN-beta-exposed pregnant women with MS from the European IFN-beta Pregnancy Registry.!##!Methods!#!Using spontaneous and solicited reports, the registry collected data from 26 countries of the European Economic Area, consisting of information on women with MS identifying themselves to one of the Marketing Authorisation Holders (Bayer, Biogen, Merck KGaA, and Novartis) or healthcare professionals as pregnant and exposed to IFN-beta during pregnancy or within 1 month before conception. The outcomes collected by the registry included ectopic pregnancies, spontaneous abortions, elective terminations, live, and stillbirths with or without congenital anomalies. The prevalence of pregnancy outcomes was put in context with those reported in the general population.!##!Results!#!Between 2009 and 2017, the registry collected 948 pregnancy reports with a known pregnancy outcome. Overall, 82.0% (777/948) of pregnancies resulted in live birth without congenital anomaly. When comparing IFN-beta-exposed pregnancies with the general population, the prevalence of spontaneous abortions (10.7% vs. 10-21%) and congenital anomalies in live births (2.1% vs. 2.1-4.1%) were found to be within reported ranges.!##!Conclusions!#!The data gathered from these pregnancy cases suggest no evidence that IFN-beta exposure before conception and/or during pregnancy adversely increases the rate of congenital anomalies or spontaneous abortions.
1000 Sacherschließung
lokal Infant, Newborn [MeSH]
lokal Abortion, Spontaneous/chemically induced [MeSH]
lokal Female [MeSH]
lokal Interferon-beta/adverse effects [MeSH]
lokal Disease-modifying drugs
lokal Congenital anomalies
lokal Pregnancy
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Prospective Studies [MeSH]
lokal Multiple Sclerosis/drug therapy [MeSH]
lokal Pregnancy Outcome/epidemiology [MeSH]
lokal Abortion, Spontaneous/epidemiology [MeSH]
lokal Europe/epidemiology [MeSH]
lokal Abnormalities, Drug-Induced/epidemiology [MeSH]
lokal Multiple sclerosis
lokal Interferon-beta
lokal Immunologic Factors/adverse effects [MeSH]
lokal Pregnancy Complications/drug therapy [MeSH]
lokal Congenital Abnormalities/epidemiology [MeSH]
lokal Spontaneous abortions
lokal Original Communication
lokal Pregnancy [MeSH]
lokal Registries [MeSH]
1000 Liste der Beteiligten
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1000 Erstellt am 2023-11-18T00:36:46.808+0100
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