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1000
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Abstract/Summary
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<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to assess the safety and effectiveness of intravascular lithotripsy (IVL) in treating eccentric calcified coronary lesions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Between December 2015 and March 2019, 180 patients were enrolled in the Disrupt CAD I and CAD II studies across 19 sites in 10 countries. Patient-level data were pooled from these two studies (<jats:italic>n</jats:italic> = 180), within which 47 eccentric lesions (26%) and 133 concentric lesions were identified.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Clinical success, defined as residual stenosis < 50% after stenting and no in-hospital MACE, was similar between the eccentric and concentric cohorts (93.6% vs. 93.2%,<jats:italic>p</jats:italic> = 1.0). There were no perforations, abrupt closure, slow flow or no reflow events observed in either group, and there were low rates of flow-limiting dissections (Grade D–F: 0% eccentric, 1.7% concentric;<jats:italic>p</jats:italic> = 0.54). Final acute gain and percent residual stenosis were similar between the two groups. Final residual stenosis of 8.6 ± 9.8% in eccentric and 10.0 ± 9.0% (<jats:italic>p</jats:italic> = 0.56) in concentric stenosis confirms the significant effect of IVL in calcified coronary lesions.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this first report from a pooled patient-level analysis of coronary IVL from the Disrupt CAD I and CAD II studies, IVL use was associated with consistent improvement in procedural and clinical outcomes in both eccentric and concentric calcified lesions.</jats:p></jats:sec>
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1000
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Hinweis
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DeepGreen-ID: 82091c65a1cc45fc90fc61f61c120b6b ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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