PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [177Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis

  1. Seifert, Robert
  2. Kessel, Katharina
  3. Schlack, Katrin
  4. Weber, Manuel
  5. Herrmann, Ken
  6. Spanke, Maximilian
  7. Fendler, Wolfgang P.
  8. Hadaschik, Boris
  9. Kleesiek, Jens
  10. Schäfers, Michael
  11. Weckesser, Matthias
  12. Boegemann, Martin
  13. Rahbar, Kambiz ORCID logo

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1000 Titel
  • PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [177Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis
1000 Autor/in
  1. Seifert, Robert |
  2. Kessel, Katharina |
  3. Schlack, Katrin |
  4. Weber, Manuel |
  5. Herrmann, Ken |
  6. Spanke, Maximilian |
  7. Fendler, Wolfgang P. |
  8. Hadaschik, Boris |
  9. Kleesiek, Jens |
  10. Schäfers, Michael |
  11. Weckesser, Matthias |
  12. Boegemann, Martin |
  13. Rahbar, Kambiz |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-24
1000 Erschienen in
1000 Quellenangabe
  • 48(4):1200-1210
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-05040-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041668/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Introduction!#![!##!Methods!#!A total number of 110 patients form the Departments of Nuclear Medicine Münster and Essen were included in this retrospective analysis. Baseline PSMA PET-CT was available for all patients. Employing a previously published approach, all tumor lesions were semi-automatically delineated in PSMA PET-CT acquisitions. Total lesion number, total tumor volume (PSMA-TV), total lesion uptake (PSMA-TLU = PSMA-TV * SUV!##!Results!#!Lesion number, PSMA-TV, and PSMA-TLQ were prognosticators of overall survival (HR = 1.255, p = 0.009; HR = 1.299, p = 0.005; HR = 1.326, p = 0.002). In a stepwise backward Cox regression including lesion number, PSMA-TV, PSA, LDH, and PSMA-TLQ, only the latter two remained independent and statistically significant negative prognosticators of overall survival (HR = 1.632, p = 0.011; HR = 1.239, p = 0.024). PSMA-TLQ and LDH were significant negative prognosticators in multivariate Cox regression in contrast to PSA value.!##!Conclusion!#!PSMA-TV was a statistically significant negative prognosticator of overall survival in patients receiving Lu-PSMA therapy. PSMA-TLQ was an independent and superior prognosticator of overall survival compared with PSMA-TV.
1000 Sacherschließung
lokal Heterocyclic Compounds, 1-Ring [MeSH]
lokal Oncology – Genitourinary
lokal Humans [MeSH]
lokal Prostate-Specific Antigen [MeSH]
lokal Treatment Outcome [MeSH]
lokal Positron Emission Tomography Computed Tomography [MeSH]
lokal Retrospective Studies [MeSH]
lokal Lu-PSMA
lokal Prostatic Neoplasms, Castration-Resistant [MeSH]
lokal PSMA
lokal Original Article
lokal PET-CT
lokal Male [MeSH]
lokal Total tumor volume
lokal Dipeptides/therapeutic use [MeSH]
lokal Tumor Burden [MeSH]
lokal mCRPC
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2VpZmVydCwgUm9iZXJ0|https://frl.publisso.de/adhoc/uri/S2Vzc2VsLCBLYXRoYXJpbmE=|https://frl.publisso.de/adhoc/uri/U2NobGFjaywgS2F0cmlu|https://frl.publisso.de/adhoc/uri/V2ViZXIsIE1hbnVlbA==|https://frl.publisso.de/adhoc/uri/SGVycm1hbm4sIEtlbg==|https://frl.publisso.de/adhoc/uri/U3BhbmtlLCBNYXhpbWlsaWFu|https://frl.publisso.de/adhoc/uri/RmVuZGxlciwgV29sZmdhbmcgUC4=|https://frl.publisso.de/adhoc/uri/SGFkYXNjaGlrLCBCb3Jpcw==|https://frl.publisso.de/adhoc/uri/S2xlZXNpZWssIEplbnM=|https://frl.publisso.de/adhoc/uri/U2Now6RmZXJzLCBNaWNoYWVs|https://frl.publisso.de/adhoc/uri/V2Vja2Vzc2VyLCBNYXR0aGlhcw==|https://frl.publisso.de/adhoc/uri/Qm9lZ2VtYW5uLCBNYXJ0aW4=|https://orcid.org/0000-0002-4591-4055
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1000 Erstellt am 2023-11-18T04:53:58.085+0100
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