18F-florbetaben positron emission tomography detects cardiac involvement in systemic AA amyloidosis

  1. Papathanasiou, Maria ORCID logo
  2. Carpinteiro, Alexander
  3. Hagenacker, Tim
  4. Herrmann, Ken
  5. Rassaf, Tienush
  6. Rischpler, Christoph
  7. Luedike, Peter

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1000 Titel
  • 18F-florbetaben positron emission tomography detects cardiac involvement in systemic AA amyloidosis
1000 Autor/in
  1. Papathanasiou, Maria |
  2. Carpinteiro, Alexander |
  3. Hagenacker, Tim |
  4. Herrmann, Ken |
  5. Rassaf, Tienush |
  6. Rischpler, Christoph |
  7. Luedike, Peter |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-05-20
1000 Erschienen in
1000 Quellenangabe
  • 47(13):3186-3187
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-04861-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680313/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Introduction!#![!##!Methods!#!A total number of 110 patients form the Departments of Nuclear Medicine Münster and Essen were included in this retrospective analysis. Baseline PSMA PET-CT was available for all patients. Employing a previously published approach, all tumor lesions were semi-automatically delineated in PSMA PET-CT acquisitions. Total lesion number, total tumor volume (PSMA-TV), total lesion uptake (PSMA-TLU = PSMA-TV * SUV!##!Results!#!Lesion number, PSMA-TV, and PSMA-TLQ were prognosticators of overall survival (HR = 1.255, p = 0.009; HR = 1.299, p = 0.005; HR = 1.326, p = 0.002). In a stepwise backward Cox regression including lesion number, PSMA-TV, PSA, LDH, and PSMA-TLQ, only the latter two remained independent and statistically significant negative prognosticators of overall survival (HR = 1.632, p = 0.011; HR = 1.239, p = 0.024). PSMA-TLQ and LDH were significant negative prognosticators in multivariate Cox regression in contrast to PSA value.!##!Conclusion!#!PSMA-TV was a statistically significant negative prognosticator of overall survival in patients receiving Lu-PSMA therapy. PSMA-TLQ was an independent and superior prognosticator of overall survival compared with PSMA-TV.
1000 Sacherschließung
lokal Tomography, X-Ray Computed [MeSH]
lokal Nuclear Medicine
lokal Image of the Month
lokal Humans [MeSH]
lokal Cardiology
lokal Imaging / Radiology
lokal Positron-Emission Tomography [MeSH]
lokal Amyloidosis/diagnostic imaging [MeSH]
lokal Aniline Compounds [MeSH]
lokal Stilbenes [MeSH]
lokal Oncology
lokal Orthopedics
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2801-7942|https://frl.publisso.de/adhoc/uri/Q2FycGludGVpcm8sIEFsZXhhbmRlcg==|https://frl.publisso.de/adhoc/uri/SGFnZW5hY2tlciwgVGlt|https://frl.publisso.de/adhoc/uri/SGVycm1hbm4sIEtlbg==|https://frl.publisso.de/adhoc/uri/UmFzc2FmLCBUaWVudXNo|https://frl.publisso.de/adhoc/uri/UmlzY2hwbGVyLCBDaHJpc3RvcGg=|https://frl.publisso.de/adhoc/uri/THVlZGlrZSwgUGV0ZXI=
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  • DeepGreen-ID: 17ae8b54a8ec4165b5afeb0568b65ea2 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-18T04:54:50.446+0100
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1000 Zuletzt bearbeitet 2023-12-01T11:24:50.326+0100
1000 Objekt bearb. Fri Dec 01 11:24:50 CET 2023
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