Reconstruction method to combine high temporal resolution with appropriate image quality in dynamic PET angiography

  1. Kühnel, Christian
  2. Seifert, Philipp
  3. Drescher, Robert
  4. Freesmeyer, Martin ORCID logo

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WeightNameValue
1000 Titel
  • Reconstruction method to combine high temporal resolution with appropriate image quality in dynamic PET angiography
1000 Autor/in
  1. Kühnel, Christian |
  2. Seifert, Philipp |
  3. Drescher, Robert |
  4. Freesmeyer, Martin |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-23
1000 Erschienen in
1000 Quellenangabe
  • 47(13):2954-2955
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-04962-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680333/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Introduction!#![!##!Methods!#!A total number of 110 patients form the Departments of Nuclear Medicine Münster and Essen were included in this retrospective analysis. Baseline PSMA PET-CT was available for all patients. Employing a previously published approach, all tumor lesions were semi-automatically delineated in PSMA PET-CT acquisitions. Total lesion number, total tumor volume (PSMA-TV), total lesion uptake (PSMA-TLU = PSMA-TV * SUV!##!Results!#!Lesion number, PSMA-TV, and PSMA-TLQ were prognosticators of overall survival (HR = 1.255, p = 0.009; HR = 1.299, p = 0.005; HR = 1.326, p = 0.002). In a stepwise backward Cox regression including lesion number, PSMA-TV, PSA, LDH, and PSMA-TLQ, only the latter two remained independent and statistically significant negative prognosticators of overall survival (HR = 1.632, p = 0.011; HR = 1.239, p = 0.024). PSMA-TLQ and LDH were significant negative prognosticators in multivariate Cox regression in contrast to PSA value.!##!Conclusion!#!PSMA-TV was a statistically significant negative prognosticator of overall survival in patients receiving Lu-PSMA therapy. PSMA-TLQ was an independent and superior prognosticator of overall survival compared with PSMA-TV.
1000 Sacherschließung
lokal Technology
lokal Behcet Syndrome [MeSH]
lokal Humans [MeSH]
lokal Imaging / Radiology
lokal Positron Emission Tomography Computed Tomography [MeSH]
lokal Letter to the Editor
lokal Oncology
lokal Angiography [MeSH]
lokal Fluorodeoxyglucose F18 [MeSH]
lokal Orthopedics
lokal Nuclear Medicine
lokal Image Processing, Computer-Assisted [MeSH]
lokal Cardiology
lokal Positron-Emission Tomography [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S8O8aG5lbCwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/U2VpZmVydCwgUGhpbGlwcA==|https://frl.publisso.de/adhoc/uri/RHJlc2NoZXIsIFJvYmVydA==|https://orcid.org/0000-0002-6462-3851
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1000 Erstellt am 2023-11-18T04:56:28.116+0100
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1000 Zuletzt bearbeitet Fri Dec 01 11:25:12 CET 2023
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