(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

  1. Tiepolt, Solveig ORCID logo
  2. Becker, Georg-Alexander
  3. Wilke, Stephan
  4. Cecchin, Diego
  5. Rullmann, Michael
  6. Meyer, Philipp M.
  7. Barthel, Henryk
  8. Hesse, Swen
  9. Patt, Marianne
  10. Luthardt, Julia
  11. Wagenknecht, Gudrun
  12. Sattler, Bernhard
  13. Deuther-Conrad, Winnie
  14. Ludwig, Friedrich-Alexander
  15. Fischer, Steffen
  16. Gertz, Hermann-Josef
  17. Smits, René
  18. Hoepping, Alexander
  19. Steinbach, Jörg
  20. Brust, Peter
  21. Sabri, Osama

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1000 Titel
  • (+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls
1000 Autor/in
  1. Tiepolt, Solveig |
  2. Becker, Georg-Alexander |
  3. Wilke, Stephan |
  4. Cecchin, Diego |
  5. Rullmann, Michael |
  6. Meyer, Philipp M. |
  7. Barthel, Henryk |
  8. Hesse, Swen |
  9. Patt, Marianne |
  10. Luthardt, Julia |
  11. Wagenknecht, Gudrun |
  12. Sattler, Bernhard |
  13. Deuther-Conrad, Winnie |
  14. Ludwig, Friedrich-Alexander |
  15. Fischer, Steffen |
  16. Gertz, Hermann-Josef |
  17. Smits, René |
  18. Hoepping, Alexander |
  19. Steinbach, Jörg |
  20. Brust, Peter |
  21. Sabri, Osama |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-16
1000 Erschienen in
1000 Quellenangabe
  • 48(3):731-746
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-05029-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036219/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purposes!#!We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)-targeting radioligand (+)-[!##!Methods!#!We examined 11 HCs and 9 mild AD patients. All subjects underwent neuropsychological testing and [!##!Results!#!With 270-min p.i., the unchanged parent compound amounted to 97 ± 2%. Adequate fits of the time-activity curves were obtained with the 1 tissue compartment model (1TCM). (+)-[!##!Conclusion!#!(+)-[
1000 Sacherschließung
lokal Neurology
lokal Brain/diagnostic imaging [MeSH]
lokal α4β2 nicotinic acetylcholine receptors
lokal Kinetic modeling
lokal Human brain
lokal Humans [MeSH]
lokal Amyloid beta-Peptides [MeSH]
lokal Aniline Compounds [MeSH]
lokal Alzheimer Disease/diagnostic imaging [MeSH]
lokal Receptors, Nicotinic [MeSH]
lokal PET
lokal Original Article
lokal Bridged Bicyclo Compounds, Heterocyclic [MeSH]
lokal Ligands [MeSH]
lokal Benzamides [MeSH]
lokal Neuroimaging [MeSH]
lokal Positron-Emission Tomography [MeSH]
lokal ( )-[
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0378-8334|https://frl.publisso.de/adhoc/uri/QmVja2VyLCBHZW9yZy1BbGV4YW5kZXI=|https://frl.publisso.de/adhoc/uri/V2lsa2UsIFN0ZXBoYW4=|https://frl.publisso.de/adhoc/uri/Q2VjY2hpbiwgRGllZ28=|https://frl.publisso.de/adhoc/uri/UnVsbG1hbm4sIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIFBoaWxpcHAgTS4=|https://frl.publisso.de/adhoc/uri/QmFydGhlbCwgSGVucnlr|https://frl.publisso.de/adhoc/uri/SGVzc2UsIFN3ZW4=|https://frl.publisso.de/adhoc/uri/UGF0dCwgTWFyaWFubmU=|https://frl.publisso.de/adhoc/uri/THV0aGFyZHQsIEp1bGlh|https://frl.publisso.de/adhoc/uri/V2FnZW5rbmVjaHQsIEd1ZHJ1bg==|https://frl.publisso.de/adhoc/uri/U2F0dGxlciwgQmVybmhhcmQ=|https://frl.publisso.de/adhoc/uri/RGV1dGhlci1Db25yYWQsIFdpbm5pZQ==|https://frl.publisso.de/adhoc/uri/THVkd2lnLCBGcmllZHJpY2gtQWxleGFuZGVy|https://frl.publisso.de/adhoc/uri/RmlzY2hlciwgU3RlZmZlbg==|https://frl.publisso.de/adhoc/uri/R2VydHosIEhlcm1hbm4tSm9zZWY=|https://frl.publisso.de/adhoc/uri/U21pdHMsIFJlbsOp|https://frl.publisso.de/adhoc/uri/SG9lcHBpbmcsIEFsZXhhbmRlcg==|https://frl.publisso.de/adhoc/uri/U3RlaW5iYWNoLCBKw7ZyZw==|https://frl.publisso.de/adhoc/uri/QnJ1c3QsIFBldGVy|https://frl.publisso.de/adhoc/uri/U2FicmksIE9zYW1h
1000 Hinweis
  • DeepGreen-ID: 3987c1730df74f2f94542e2eef9a1c96 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-18T05:08:05.325+0100
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1000 Zuletzt bearbeitet 2023-12-01T11:27:54.328+0100
1000 Objekt bearb. Fri Dec 01 11:27:54 CET 2023
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