18F-PSMA-1007 PET/CT for response assessment in patients with metastatic renal cell carcinoma undergoing tyrosine kinase or checkpoint inhibitor therapy: preliminary results

  1. Mittlmeier, L. M.
  2. Unterrainer, M.
  3. Rodler, S.
  4. Todica, A.
  5. Albert, N. L.
  6. Burgard, C.
  7. Cyran, C. C.
  8. Kunz, W. G.
  9. Ricke, J.
  10. Bartenstein, P.
  11. Stief, C. G.
  12. Ilhan, H.
  13. Staehler, M.

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1000 Titel
  • 18F-PSMA-1007 PET/CT for response assessment in patients with metastatic renal cell carcinoma undergoing tyrosine kinase or checkpoint inhibitor therapy: preliminary results
1000 Autor/in
  1. Mittlmeier, L. M. |
  2. Unterrainer, M. |
  3. Rodler, S. |
  4. Todica, A. |
  5. Albert, N. L. |
  6. Burgard, C. |
  7. Cyran, C. C. |
  8. Kunz, W. G. |
  9. Ricke, J. |
  10. Bartenstein, P. |
  11. Stief, C. G. |
  12. Ilhan, H. |
  13. Staehler, M. |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-12-28
1000 Erschienen in
1000 Quellenangabe
  • 48(6):2031-2037
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00259-020-05165-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113284/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Introduction!#!Tyrosine kinase (TKI) and checkpoint inhibitors (CI) prolonged overall survival in metastatic renal cell carcinoma (mRCC). Early prediction of treatment response is highly desirable for the individualization of patient management and improvement of therapeutic outcome; however, serum biochemistry is unable to predict therapeutic efficacy. Therefore, we compared !##!Methods!#!18!##!Results!#!Overall, 11 mRCC patients undergoing systemic treatment were included. At baseline PSMA-PET!##!Conclusion!#!On PSMA-PET, heterogeneous courses were observed during systemic treatment in mRCC patients with highly diverging results compared to RECIST 1.1. In the light of missing biomarkers for early response assessment, PSMA-PET might allow more precise response assessment to systemic treatment, especially in patients classified as SD on CT.
1000 Sacherschließung
lokal Carcinoma, Renal Cell/diagnostic imaging [MeSH]
lokal Protein-Tyrosine Kinases [MeSH]
lokal Humans [MeSH]
lokal Immune Checkpoint Inhibitors [MeSH]
lokal Positron Emission Tomography Computed Tomography [MeSH]
lokal Radiopharmaceuticals [MeSH]
lokal Response assessment
lokal Checkpoint inhibitor therapy
lokal Kidney Neoplasms/diagnostic imaging [MeSH]
lokal Kidney Neoplasms/drug therapy [MeSH]
lokal Original Article
lokal CT
lokal Carcinoma, Renal Cell/drug therapy [MeSH]
lokal Niacinamide/analogs
lokal Tyrosine kinase therapy
lokal Fluorine Radioisotopes [MeSH]
lokal Metastatic renal cell carcinoma
lokal Oncology – General
lokal Oligopeptides [MeSH]
lokal Protein Kinase Inhibitors [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWl0dGxtZWllciwgTC4gTS4=|https://frl.publisso.de/adhoc/uri/VW50ZXJyYWluZXIsIE0u|https://frl.publisso.de/adhoc/uri/Um9kbGVyLCBTLg==|https://frl.publisso.de/adhoc/uri/VG9kaWNhLCBBLg==|https://frl.publisso.de/adhoc/uri/QWxiZXJ0LCBOLiBMLg==|https://frl.publisso.de/adhoc/uri/QnVyZ2FyZCwgQy4=|https://frl.publisso.de/adhoc/uri/Q3lyYW4sIEMuIEMu|https://frl.publisso.de/adhoc/uri/S3VueiwgVy4gRy4=|https://frl.publisso.de/adhoc/uri/Umlja2UsIEou|https://frl.publisso.de/adhoc/uri/QmFydGVuc3RlaW4sIFAu|https://frl.publisso.de/adhoc/uri/U3RpZWYsIEMuIEcu|https://frl.publisso.de/adhoc/uri/SWxoYW4sIEgu|https://frl.publisso.de/adhoc/uri/U3RhZWhsZXIsIE0u
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1000 Erstellt am 2023-11-18T05:21:37.733+0100
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1000 Zuletzt bearbeitet Fri Dec 01 11:30:14 CET 2023
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