Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival

  1. Karstens, Karl-Frederick
  2. Kempski, Jan
  3. Giannou, Anastasios D.
  4. Pelczar, Penelope
  5. Steglich, Babett
  6. Steurer, Stefan
  7. Freiwald, Eric
  8. Woestemeier, Anna
  9. Konczalla, Leonie
  10. Tachezy, Michael
  11. Reeh, Matthias
  12. Bockhorn, Maximilian
  13. Perez, Daniel
  14. Mann, Oliver
  15. Lohse, Ansgar W.
  16. Roesch, Thomas
  17. Izbicki, Jakob R.
  18. Gagliani, Nicola
  19. Huber, Samuel ORCID logo

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WeightNameValue
1000 Titel
  • Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival
1000 Autor/in
  1. Karstens, Karl-Frederick |
  2. Kempski, Jan |
  3. Giannou, Anastasios D. |
  4. Pelczar, Penelope |
  5. Steglich, Babett |
  6. Steurer, Stefan |
  7. Freiwald, Eric |
  8. Woestemeier, Anna |
  9. Konczalla, Leonie |
  10. Tachezy, Michael |
  11. Reeh, Matthias |
  12. Bockhorn, Maximilian |
  13. Perez, Daniel |
  14. Mann, Oliver |
  15. Lohse, Ansgar W. |
  16. Roesch, Thomas |
  17. Izbicki, Jakob R. |
  18. Gagliani, Nicola |
  19. Huber, Samuel |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-25
1000 Erschienen in
1000 Quellenangabe
  • 69(6):1043-1056
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00262-020-02517-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230052/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Objective!#!Reflux promotes esophageal adenocarcinomas (EACs) creating a chronic inflammatory environment. Survival rates are low due to early local recurrences and distant metastasis. Hence, there is a need for new potential treatment options like immunotherapies. However, the inflammatory microenvironment in EACs and its impact on patient outcome remain to be fully understood.!##!Methods!#!mRNA expression levels of pro- and anti-inflammatory markers in 39 EAC patients without neoadjuvant radio-chemotherapy were measured. Data were confirmed using flow cytometric analysis of freshly resected surgical specimens. Inflammatory alterations in premalignant lesions of Barrett's esophagus were analyzed by immunohistochemistry.!##!Results!#!Expression levels of IL22 were reduced in EAC, while expression levels of FOXP3, IL10 and CTLA4 were increased. Flow cytometry demonstrated a strong infiltration of CD4!##!Conclusion!#!EAC shows an anti-inflammatory environment, which strongly affects patient survival. The microscopically unaltered peritumoral tissue shows a similar anti-inflammatory pattern indicating an immunological field effect, which might contribute to early local recurrences despite radical resection. These data suggest that using checkpoint inhibitors targeting anti-inflammatory T cells would be a promising therapeutic strategy in EAC.
1000 Sacherschließung
lokal Female [MeSH]
lokal Humans [MeSH]
lokal Survival Analysis [MeSH]
lokal Retrospective Studies [MeSH]
lokal Original Article
lokal Anti-Inflammatory Agents/pharmacology [MeSH]
lokal Survival
lokal Male [MeSH]
lokal Anti-Inflammatory Agents/therapeutic use [MeSH]
lokal Esophageal Neoplasms/mortality [MeSH]
lokal Esophageal Neoplasms/physiopathology [MeSH]
lokal Esophageal adenocarcinoma
lokal Barrett’s esophagus
lokal Adenocarcinoma/mortality [MeSH]
lokal Anti-inflammatory environment
lokal Adenocarcinoma/physiopathology [MeSH]
lokal Tumor Microenvironment [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2Fyc3RlbnMsIEthcmwtRnJlZGVyaWNr|https://frl.publisso.de/adhoc/uri/S2VtcHNraSwgSmFu|https://frl.publisso.de/adhoc/uri/R2lhbm5vdSwgQW5hc3Rhc2lvcyBELg==|https://frl.publisso.de/adhoc/uri/UGVsY3phciwgUGVuZWxvcGU=|https://frl.publisso.de/adhoc/uri/U3RlZ2xpY2gsIEJhYmV0dA==|https://frl.publisso.de/adhoc/uri/U3RldXJlciwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/RnJlaXdhbGQsIEVyaWM=|https://frl.publisso.de/adhoc/uri/V29lc3RlbWVpZXIsIEFubmE=|https://frl.publisso.de/adhoc/uri/S29uY3phbGxhLCBMZW9uaWU=|https://frl.publisso.de/adhoc/uri/VGFjaGV6eSwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/UmVlaCwgTWF0dGhpYXM=|https://frl.publisso.de/adhoc/uri/Qm9ja2hvcm4sIE1heGltaWxpYW4=|https://frl.publisso.de/adhoc/uri/UGVyZXosIERhbmllbA==|https://frl.publisso.de/adhoc/uri/TWFubiwgT2xpdmVy|https://frl.publisso.de/adhoc/uri/TG9oc2UsIEFuc2dhciBXLg==|https://frl.publisso.de/adhoc/uri/Um9lc2NoLCBUaG9tYXM=|https://frl.publisso.de/adhoc/uri/SXpiaWNraSwgSmFrb2IgUi4=|https://frl.publisso.de/adhoc/uri/R2FnbGlhbmksIE5pY29sYQ==|https://orcid.org/0000-0001-9325-8227
1000 Hinweis
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1000 Erstellt am 2023-11-18T05:33:41.108+0100
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