The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis

  1. Ghashghaeinia, Mehrdad ORCID logo
  2. Koralkova, Pavla ORCID logo
  3. Giustarini, Daniela
  4. Mojzikova, Renata
  5. Fehrenbacher, Birgit
  6. Dreischer, Peter
  7. Schaller, Martin
  8. Mrowietz, Ulrich
  9. Martínez-Ruiz, Antonio ORCID logo
  10. Wieder, Thomas
  11. Divoký, Vladimír ORCID logo
  12. Rossi, Ranieri
  13. Lang, Florian
  14. Köberle, Martin ORCID logo

Download
s10495-020-01620-6.pdf 873,67KB
WeightNameValue
1000 Titel
  • The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
1000 Autor/in
  1. Ghashghaeinia, Mehrdad |
  2. Koralkova, Pavla |
  3. Giustarini, Daniela |
  4. Mojzikova, Renata |
  5. Fehrenbacher, Birgit |
  6. Dreischer, Peter |
  7. Schaller, Martin |
  8. Mrowietz, Ulrich |
  9. Martínez-Ruiz, Antonio |
  10. Wieder, Thomas |
  11. Divoký, Vladimír |
  12. Rossi, Ranieri |
  13. Lang, Florian |
  14. Köberle, Martin |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-07-07
1000 Erschienen in
1000 Quellenangabe
  • 25(9-10):674-685
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10495-020-01620-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527323/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. glutathione and glucose-6-phosphate dehydrogenase (G6PDH) respectively, have not been studied yet. Our aim was to determine the mechanisms underlying costunolide-induced eryptosis and to reverse this process. Phosphatidylserine exposure was estimated from annexin-V-binding, cell volume from forward scatter in flow cytometry, and intracellular glutathione [GSH]
1000 Sacherschließung
lokal Costunolide
lokal Glutathione
lokal Calcium/metabolism [MeSH]
lokal Glucosephosphate Dehydrogenase/antagonists
lokal Glutathione/genetics [MeSH]
lokal Humans [MeSH]
lokal Apoptosis/drug effects [MeSH]
lokal Eryptosis/drug effects [MeSH]
lokal Erythrocytes/drug effects [MeSH]
lokal Erythrocytes/pathology [MeSH]
lokal Enzyme Inhibitors/pharmacology [MeSH]
lokal Protein Kinase C-alpha/genetics [MeSH]
lokal Article
lokal Eryptosis
lokal Eryptosis/genetics [MeSH]
lokal Sesquiterpenes/pharmacology [MeSH]
lokal Phosphatidylserine exposure
lokal Oxidative Stress/drug effects [MeSH]
lokal Benzophenanthridines/pharmacology [MeSH]
lokal Glucosephosphate Dehydrogenase/genetics [MeSH]
lokal Protein Kinase C-alpha/antagonists
lokal Chelerythrine
lokal Reactive Oxygen Species [MeSH]
lokal Glucose-6-phosphate dehydrogenase (G6PDH)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1740-594X|https://orcid.org/0000-0001-7970-1501|https://frl.publisso.de/adhoc/uri/R2l1c3RhcmluaSwgRGFuaWVsYQ==|https://frl.publisso.de/adhoc/uri/TW9qemlrb3ZhLCBSZW5hdGE=|https://frl.publisso.de/adhoc/uri/RmVocmVuYmFjaGVyLCBCaXJnaXQ=|https://frl.publisso.de/adhoc/uri/RHJlaXNjaGVyLCBQZXRlcg==|https://frl.publisso.de/adhoc/uri/U2NoYWxsZXIsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/TXJvd2lldHosIFVscmljaA==|https://orcid.org/0000-0001-5394-9824|https://frl.publisso.de/adhoc/uri/V2llZGVyLCBUaG9tYXM=|https://orcid.org/0000-0003-0202-245X|https://frl.publisso.de/adhoc/uri/Um9zc2ksIFJhbmllcmk=|https://frl.publisso.de/adhoc/uri/TGFuZywgRmxvcmlhbg==|https://orcid.org/0000-0001-6825-2667
1000 Hinweis
  • DeepGreen-ID: d4a6642fcd2a499e9f94890411d0c44e ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6470656.rdf
1000 Erstellt am 2023-11-18T07:56:18.370+0100
1000 Erstellt von 322
1000 beschreibt frl:6470656
1000 Zuletzt bearbeitet Fri Dec 01 12:36:01 CET 2023
1000 Objekt bearb. Fri Dec 01 12:36:01 CET 2023
1000 Vgl. frl:6470656
1000 Oai Id
  1. oai:frl.publisso.de:frl:6470656 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source