Download
s41375-020-0917-7.pdf 3,39MB
WeightNameValue
1000 Titel
  • Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification—an approach to classification of patients with t-MDS
1000 Autor/in
  1. Kuendgen, Andrea |
  2. Nomdedeu, M. |
  3. Tuechler, Heinz |
  4. Garcia-Manero, G. |
  5. Komrokji, R. S. |
  6. Sekeres, M. A. |
  7. Della Porta, M. G. |
  8. Cazzola, Mario |
  9. DeZern, A. E. |
  10. Roboz, G. J. |
  11. Steensma, David |
  12. Van de Loosdrecht, A. A. |
  13. Schlenk, Richard F |
  14. Grau, J. |
  15. Calvo, Xavier |
  16. Blum, Sabine |
  17. Pereira, A. |
  18. Valent, P. |
  19. Costa, D. |
  20. Giagounidis, A. |
  21. Xicoy, B. |
  22. Döhner, H. |
  23. Platzbecker, U. |
  24. Pedro, C. |
  25. Lübbert, M. |
  26. Oiartzabal, I. |
  27. Díez-Campelo, M. |
  28. Cedena, M. T. |
  29. Machherndl-Spandl, S. |
  30. López-Pavía, M. |
  31. Baldus, C. D. |
  32. Martinez-de-Sola, M. |
  33. Stauder, R. |
  34. Merchan, B. |
  35. List, A. |
  36. Ganster, Christina |
  37. Schroeder, T. |
  38. VOSO, Maria Teresa |
  39. Pfeilstöcker, M. |
  40. Sill, H. |
  41. Hildebrandt, B. |
  42. Esteve, J. |
  43. Nomdedeu, B. |
  44. Cobo, F. |
  45. Haas, R. |
  46. Sole, F. |
  47. Germing, U. |
  48. Greenberg, P. L. |
  49. Haase, D. |
  50. SANZ, GUILLERMO |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-29
1000 Erschienen in
1000 Quellenangabe
  • 35(3):835-849
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41375-020-0917-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932916/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In the current World Health Organization (WHO)-classification, therapy-related myelodysplastic syndromes (t-MDS) are categorized together with therapy-related acute myeloid leukemia (AML) and t-myelodysplastic/myeloproliferative neoplasms into one subgroup independent of morphologic or prognostic features. Analyzing data of 2087 t-MDS patients from different international MDS groups to evaluate classification and prognostication tools we found that applying the WHO classification for p-MDS successfully predicts time to transformation and survival (both p < 0.001). The results regarding carefully reviewed cytogenetic data, classifications, and prognostic scores confirmed that t-MDS are similarly heterogeneous as p-MDS and therefore deserve the same careful differentiation regarding risk. As reference, these results were compared with 4593 primary MDS (p-MDS) patients represented in the International Working Group for Prognosis in MDS database (IWG-PM). Although a less favorable clinical outcome occurred in each t-MDS subset compared with p-MDS subgroups, FAB and WHO-classification, IPSS-R, and WPSS-R separated t-MDS patients into differing risk groups effectively, indicating that all established risk factors for p-MDS maintained relevance in t-MDS, with cytogenetic features having enhanced predictive power. These data strongly argue to classify t-MDS as a separate entity distinct from other WHO-classified t-myeloid neoplasms, which would enhance treatment decisions and facilitate the inclusion of t-MDS patients into clinical studies.
1000 Sacherschließung
lokal Female [MeSH]
lokal Follow-Up Studies [MeSH]
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Neoplasms, Second Primary/classification [MeSH]
lokal Humans [MeSH]
lokal Myelodysplastic Syndromes/therapy [MeSH]
lokal Neoplasms, Second Primary/diagnosis [MeSH]
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Risk factors
lokal Survival Rate [MeSH]
lokal Article
lokal Male [MeSH]
lokal Neoplasms, Second Primary/therapy [MeSH]
lokal Prognosis [MeSH]
lokal Diagnosis
lokal Myelodysplastic Syndromes/classification [MeSH]
lokal Biomarkers, Tumor/analysis [MeSH]
lokal Myelodysplastic Syndromes/diagnosis [MeSH]
lokal Risk Assessment/methods [MeSH]
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1833-1890|https://frl.publisso.de/adhoc/uri/Tm9tZGVkZXUsIE0u|https://orcid.org/0000-0002-1568-3436|https://frl.publisso.de/adhoc/uri/R2FyY2lhLU1hbmVybywgRy4=|https://frl.publisso.de/adhoc/uri/S29tcm9ramksIFIuIFMu|https://frl.publisso.de/adhoc/uri/U2VrZXJlcywgTS4gQS4=|https://frl.publisso.de/adhoc/uri/RGVsbGEgUG9ydGEsIE0uIEcu|https://orcid.org/0000-0001-6984-8817|https://frl.publisso.de/adhoc/uri/RGVaZXJuLCBBLiBFLg==|https://frl.publisso.de/adhoc/uri/Um9ib3osIEcuIEou|https://orcid.org/0000-0001-5130-9284|https://frl.publisso.de/adhoc/uri/VmFuIGRlIExvb3NkcmVjaHQsIEEuIEEu|https://orcid.org/0000-0003-2215-2059|https://frl.publisso.de/adhoc/uri/R3JhdSwgSi4=|https://orcid.org/0000-0001-7934-9130|https://orcid.org/0000-0003-2275-3081|https://frl.publisso.de/adhoc/uri/UGVyZWlyYSwgQS4=|https://frl.publisso.de/adhoc/uri/VmFsZW50LCBQLg==|https://frl.publisso.de/adhoc/uri/Q29zdGEsIEQu|https://frl.publisso.de/adhoc/uri/R2lhZ291bmlkaXMsIEEu|https://frl.publisso.de/adhoc/uri/WGljb3ksIEIu|https://frl.publisso.de/adhoc/uri/RMO2aG5lciwgSC4=|https://frl.publisso.de/adhoc/uri/UGxhdHpiZWNrZXIsIFUu|https://frl.publisso.de/adhoc/uri/UGVkcm8sIEMu|https://frl.publisso.de/adhoc/uri/TMO8YmJlcnQsIE0u|https://frl.publisso.de/adhoc/uri/T2lhcnR6YWJhbCwgSS4=|https://frl.publisso.de/adhoc/uri/RMOtZXotQ2FtcGVsbywgTS4=|https://frl.publisso.de/adhoc/uri/Q2VkZW5hLCBNLiBULg==|https://frl.publisso.de/adhoc/uri/TWFjaGhlcm5kbC1TcGFuZGwsIFMu|https://frl.publisso.de/adhoc/uri/TMOzcGV6LVBhdsOtYSwgTS4=|https://frl.publisso.de/adhoc/uri/QmFsZHVzLCBDLiBELg==|https://frl.publisso.de/adhoc/uri/TWFydGluZXotZGUtU29sYSwgTS4=|https://frl.publisso.de/adhoc/uri/U3RhdWRlciwgUi4=|https://frl.publisso.de/adhoc/uri/TWVyY2hhbiwgQi4=|https://frl.publisso.de/adhoc/uri/TGlzdCwgQS4=|https://orcid.org/0000-0002-7566-5985|https://frl.publisso.de/adhoc/uri/U2Nocm9lZGVyLCBULg==|https://orcid.org/0000-0002-6164-4761|https://frl.publisso.de/adhoc/uri/UGZlaWxzdMO2Y2tlciwgTS4=|https://frl.publisso.de/adhoc/uri/U2lsbCwgSC4=|https://frl.publisso.de/adhoc/uri/SGlsZGVicmFuZHQsIEIu|https://frl.publisso.de/adhoc/uri/RXN0ZXZlLCBKLg==|https://frl.publisso.de/adhoc/uri/Tm9tZGVkZXUsIEIu|https://frl.publisso.de/adhoc/uri/Q29ibywgRi4=|https://frl.publisso.de/adhoc/uri/SGFhcywgUi4=|https://frl.publisso.de/adhoc/uri/U29sZSwgRi4=|https://frl.publisso.de/adhoc/uri/R2VybWluZywgVS4=|https://frl.publisso.de/adhoc/uri/R3JlZW5iZXJnLCBQLiBMLg==|https://frl.publisso.de/adhoc/uri/SGFhc2UsIEQu|https://orcid.org/0000-0002-2767-8191
1000 Hinweis
  • DeepGreen-ID: 1947b8c54da14014b7a3b083b9b9913b ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6471060.rdf
1000 Erstellt am 2023-11-18T10:38:29.441+0100
1000 Erstellt von 322
1000 beschreibt frl:6471060
1000 Zuletzt bearbeitet 2023-12-01T13:35:58.395+0100
1000 Objekt bearb. Fri Dec 01 13:35:58 CET 2023
1000 Vgl. frl:6471060
1000 Oai Id
  1. oai:frl.publisso.de:frl:6471060 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source