The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

  1. Jessen, Christina
  2. Kreß, Julia ORCID logo
  3. Baluapuri, Apoorva ORCID logo
  4. Hufnagel, Anita
  5. Schmitz, Werner ORCID logo
  6. Kneitz, Susanne
  7. Roth, Sabine
  8. Marquardt, André
  9. Appenzeller, Silke
  10. Ade, Carsten ORCID logo
  11. Glutsch, Valerie
  12. Wobser, Marion
  13. Friedmann Angeli, Jose Pedro ORCID logo
  14. Mosteo, Laura
  15. Goding, Colin ORCID logo
  16. Schilling, Bastian ORCID logo
  17. Geissinger, Eva
  18. Wolf, Elmar ORCID logo
  19. Meierjohann, Svenja ORCID logo

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WeightNameValue
1000 Titel
  • The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
1000 Autor/in
  1. Jessen, Christina |
  2. Kreß, Julia |
  3. Baluapuri, Apoorva |
  4. Hufnagel, Anita |
  5. Schmitz, Werner |
  6. Kneitz, Susanne |
  7. Roth, Sabine |
  8. Marquardt, André |
  9. Appenzeller, Silke |
  10. Ade, Carsten |
  11. Glutsch, Valerie |
  12. Wobser, Marion |
  13. Friedmann Angeli, Jose Pedro |
  14. Mosteo, Laura |
  15. Goding, Colin |
  16. Schilling, Bastian |
  17. Geissinger, Eva |
  18. Wolf, Elmar |
  19. Meierjohann, Svenja |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-25
1000 Erschienen in
1000 Quellenangabe
  • 39(44):6841-6855
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41388-020-01477-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605435/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is unclear to what extent melanomas rely on NRF2. Here we show that NRF2 suppresses the activity of the melanocyte lineage marker MITF in melanoma, thereby reducing the expression of pigmentation markers. Intriguingly, we furthermore identified NRF2 as key regulator of immune-modulating genes, linking oxidative stress with the induction of cyclooxygenase 2 (COX2) in an ATF4-dependent manner. COX2 is critical for the secretion of prostaglandin E2 and was strongly induced by H
1000 Sacherschließung
lokal Cell Line, Tumor [MeSH]
lokal Immunity, Innate/genetics [MeSH]
lokal Gene Expression Regulation, Neoplastic/immunology [MeSH]
lokal Melanoma
lokal Lung Neoplasms/genetics [MeSH]
lokal Tumor Escape/genetics [MeSH]
lokal NF-E2-Related Factor 2/metabolism [MeSH]
lokal NF-E2-Related Factor 2/genetics [MeSH]
lokal Activating Transcription Factor 4/metabolism [MeSH]
lokal Gene Knockout Techniques [MeSH]
lokal Male [MeSH]
lokal Adenocarcinoma of Lung/genetics [MeSH]
lokal Melanoma/pathology [MeSH]
lokal Lung Neoplasms/immunology [MeSH]
lokal Microphthalmia-Associated Transcription Factor/metabolism [MeSH]
lokal Skin Neoplasms/immunology [MeSH]
lokal Disease Models, Animal [MeSH]
lokal Female [MeSH]
lokal Oncogenes
lokal Melanoma/genetics [MeSH]
lokal Datasets as Topic [MeSH]
lokal Humans [MeSH]
lokal Gene Knockdown Techniques [MeSH]
lokal Cell Differentiation/genetics [MeSH]
lokal Adenocarcinoma of Lung/immunology [MeSH]
lokal Skin Neoplasms/pathology [MeSH]
lokal Animals [MeSH]
lokal Mice [MeSH]
lokal Article
lokal Skin Neoplasms/genetics [MeSH]
lokal Melanoma/immunology [MeSH]
lokal Lung Neoplasms/pathology [MeSH]
lokal Dinoprostone/metabolism [MeSH]
lokal Cyclooxygenase 2/metabolism [MeSH]
lokal Adenocarcinoma of Lung/pathology [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SmVzc2VuLCBDaHJpc3RpbmE=|https://orcid.org/0000-0002-7391-0406|https://orcid.org/0000-0002-3723-7891|https://frl.publisso.de/adhoc/uri/SHVmbmFnZWwsIEFuaXRh|https://orcid.org/0000-0003-0485-7303|https://frl.publisso.de/adhoc/uri/S25laXR6LCBTdXNhbm5l|https://frl.publisso.de/adhoc/uri/Um90aCwgU2FiaW5l|https://frl.publisso.de/adhoc/uri/TWFycXVhcmR0LCBBbmRyw6k=|https://frl.publisso.de/adhoc/uri/QXBwZW56ZWxsZXIsIFNpbGtl|https://orcid.org/0000-0001-7226-1179|https://frl.publisso.de/adhoc/uri/R2x1dHNjaCwgVmFsZXJpZQ==|https://frl.publisso.de/adhoc/uri/V29ic2VyLCBNYXJpb24=|https://orcid.org/0000-0001-7706-1379|https://frl.publisso.de/adhoc/uri/TW9zdGVvLCBMYXVyYQ==|https://orcid.org/0000-0002-1614-3909|https://orcid.org/0000-0001-8859-4103|https://frl.publisso.de/adhoc/uri/R2Vpc3NpbmdlciwgRXZh|https://orcid.org/0000-0002-5299-6335|https://orcid.org/0000-0002-9058-7196
1000 Hinweis
  • DeepGreen-ID: fa54e1cdefc04159868e63de9dd6d6af ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-18T12:34:57.714+0100
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1000 Zuletzt bearbeitet Fri Dec 01 14:08:32 CET 2023
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