The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells

  1. Schmidt, Ann-Kathrin ORCID logo
  2. Pudelko, Karoline
  3. Boekenkamp, Jan-Eric
  4. Berger, Katharina
  5. Kschischo, Maik ORCID logo
  6. Bastians, Holger ORCID logo

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WeightNameValue
1000 Titel
  • The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells
1000 Autor/in
  1. Schmidt, Ann-Kathrin |
  2. Pudelko, Karoline |
  3. Boekenkamp, Jan-Eric |
  4. Berger, Katharina |
  5. Kschischo, Maik |
  6. Bastians, Holger |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-09
1000 Erschienen in
1000 Quellenangabe
  • 40(2):436-451
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41388-020-01524-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808936/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human cancer cells. Here, we show that loss of the tumor suppressor genes TP53 and TP73 can trigger increased mitotic microtubule assembly rates, lagging chromosomes, and W-CIN. CDKN1A, encoding for the CDK inhibitor p21
1000 Sacherschließung
lokal Cyclin-Dependent Kinase Inhibitor p21/metabolism [MeSH]
lokal Gene Expression Regulation, Neoplastic [MeSH]
lokal Cell Proliferation [MeSH]
lokal Cyclin-Dependent Kinase Inhibitor p21/genetics [MeSH]
lokal CDC2 Protein Kinase/metabolism [MeSH]
lokal Humans [MeSH]
lokal CDC2 Protein Kinase/genetics [MeSH]
lokal Tumor Suppressor Protein p53/metabolism [MeSH]
lokal Colonic Neoplasms/genetics [MeSH]
lokal Apoptosis [MeSH]
lokal Tumor Suppressor Protein p53/genetics [MeSH]
lokal Chromosomal Instability [MeSH]
lokal Tumor Cells, Cultured [MeSH]
lokal Tumor Protein p73/metabolism [MeSH]
lokal Article
lokal Biomarkers, Tumor/metabolism [MeSH]
lokal Biomarkers, Tumor/genetics [MeSH]
lokal Colonic Neoplasms/pathology [MeSH]
lokal Colonic Neoplasms/metabolism [MeSH]
lokal Cancer genomics
lokal Tumor Protein p73/genetics [MeSH]
lokal Mitosis
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8100-5177|https://frl.publisso.de/adhoc/uri/UHVkZWxrbywgS2Fyb2xpbmU=|https://frl.publisso.de/adhoc/uri/Qm9la2Vua2FtcCwgSmFuLUVyaWM=|https://frl.publisso.de/adhoc/uri/QmVyZ2VyLCBLYXRoYXJpbmE=|https://orcid.org/0000-0003-3977-9982|https://orcid.org/0000-0001-7915-3648
1000 Hinweis
  • DeepGreen-ID: f9e2e39e8738435fb1e31c32a9b1d639 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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1000 Erstellt am 2023-11-18T12:38:39.594+0100
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1000 Objekt bearb. Fri Dec 01 14:09:54 CET 2023
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