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1000 Titel
  • Hypocaloric Diet Initiated Post-Ischemia Provides Long-Term Neuroprotection and Promotes Peri-Infarct Brain Remodeling by Regulating Metabolic and Survival-Promoting Proteins
1000 Autor/in
  1. de Carvalho, Tayana Silva |
  2. Sanchez-Mendoza, Eduardo H. |
  3. Schultz Moreira, Adriana R. |
  4. Nascentes Melo, Luiza M. |
  5. Wang, Chen |
  6. Sardari, Maryam |
  7. Hagemann, Nina |
  8. Doeppner, Thorsten R. |
  9. Kleinschnitz, Christoph |
  10. Hermann, Dirk |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-11-17
1000 Erschienen in
1000 Quellenangabe
  • 58(4):1491-1503
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12035-020-02207-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932971/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How a hypocaloric diet influences stroke recovery when initiated after stroke has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately post-ischemia, mice were randomized to two groups receiving moderately hypocaloric (2286 kcal/kg food) or normocaloric (3518 kcal/kg) diets ad libitum. Animals were sacrificed at 3 or 56 days post-ischemia (dpi). Besides increased low density lipoprotein at 3 days and reduced alanine aminotransferase and increased urea at 56 days, no alterations of plasma markers were found in ischemic mice on hypocaloric diet. Body weight mildly decreased over 56 dpi by 7.4%. Hypocaloric diet reduced infarct volume in the acute stroke phase at 3 dpi and decreased brain atrophy, increased neuronal survival and brain capillary density in peri-infarct striatum and reduced motor coordination impairment in tight rope tests in the post-acute stroke phase over up to 56 dpi. The abundance of brain-derived neurotrophic factor, the NAD-dependent deacetylase and longevity protein sirtuin-1, the anti-oxidant glutathione peroxidase-3, and the ammonium detoxifier glutamine synthetase in the peri-infarct brain tissue was increased by hypocaloric diet. This study shows that a moderately hypocaloric diet that is initiated after stroke confers long-term neuroprotection and promotes peri-infarct brain remodeling.
1000 Sacherschließung
lokal Brain Ischemia/blood [MeSH]
lokal Atrophy [MeSH]
lokal Mice, Inbred C57BL [MeSH]
lokal Brain Ischemia/metabolism [MeSH]
lokal Liver/metabolism [MeSH]
lokal Nerve Tissue Proteins/metabolism [MeSH]
lokal NAD/metabolism [MeSH]
lokal Cerebral Infarction/metabolism [MeSH]
lokal Sirtuin 1/metabolism [MeSH]
lokal Male [MeSH]
lokal Neuroprotection [MeSH]
lokal Stroke/blood [MeSH]
lokal Capillaries/pathology [MeSH]
lokal Antioxidants/metabolism [MeSH]
lokal Cerebral Infarction/blood [MeSH]
lokal Brain/pathology [MeSH]
lokal Sirtuin-1
lokal Stroke/pathology [MeSH]
lokal Survival Analysis [MeSH]
lokal Animals [MeSH]
lokal Brain Ischemia/complications [MeSH]
lokal Glutathione Peroxidase/metabolism [MeSH]
lokal Time Factors [MeSH]
lokal Article
lokal Neurological recovery
lokal Neuroprotection
lokal Cerebral Infarction/pathology [MeSH]
lokal Calorie restriction
lokal Brain Ischemia/pathology [MeSH]
lokal Diet, Reducing [MeSH]
lokal Ischemic stroke
lokal Cerebral Infarction/complications [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/ZGUgQ2FydmFsaG8sIFRheWFuYSBTaWx2YQ==|https://frl.publisso.de/adhoc/uri/U2FuY2hlei1NZW5kb3phLCBFZHVhcmRvIEgu|https://frl.publisso.de/adhoc/uri/U2NodWx0eiBNb3JlaXJhLCBBZHJpYW5hIFIu|https://frl.publisso.de/adhoc/uri/TmFzY2VudGVzIE1lbG8sIEx1aXphIE0u|https://frl.publisso.de/adhoc/uri/V2FuZywgQ2hlbg==|https://frl.publisso.de/adhoc/uri/U2FyZGFyaSwgTWFyeWFt|https://frl.publisso.de/adhoc/uri/SGFnZW1hbm4sIE5pbmE=|https://frl.publisso.de/adhoc/uri/RG9lcHBuZXIsIFRob3JzdGVuIFIu|https://frl.publisso.de/adhoc/uri/S2xlaW5zY2huaXR6LCBDaHJpc3RvcGg=|https://orcid.org/0000-0003-0198-3152
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1000 Erstellt am 2023-11-18T15:24:51.646+0100
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