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1000 Titel
  • Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease
1000 Autor/in
  1. Meyer, Fabian |
  2. Seibert, Felix S. |
  3. Nienen, Mikalai |
  4. Welzel, Marius |
  5. Beisser, Daniela |
  6. Bauer, Frederic |
  7. Rohn, Benjamin |
  8. Westhoff, Timm H. |
  9. Stervbo, Ulrik |
  10. Babel, Nina |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-03-06
1000 Erschienen in
1000 Quellenangabe
  • 33(4):817-827
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s40620-019-00694-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381474/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of CD25
1000 Sacherschließung
lokal Propionates/administration
lokal Female [MeSH]
lokal End-stage renal disease
lokal Aged, 80 and over [MeSH]
lokal Aged [MeSH]
lokal Regulatory T-cells
lokal Adult [MeSH]
lokal Flow Cytometry [MeSH]
lokal Humans [MeSH]
lokal T-Lymphocytes, Regulatory/immunology [MeSH]
lokal Middle Aged [MeSH]
lokal T-Lymphocytes, Regulatory/drug effects [MeSH]
lokal Original Article
lokal Male [MeSH]
lokal Dietary Supplements [MeSH]
lokal Young Adult [MeSH]
lokal Case-Control Studies [MeSH]
lokal Kidney Failure, Chronic/immunology [MeSH]
lokal Short-chain fatty acids
lokal Propionate
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWV5ZXIsIEZhYmlhbg==|https://frl.publisso.de/adhoc/uri/U2VpYmVydCwgRmVsaXggUy4=|https://frl.publisso.de/adhoc/uri/TmllbmVuLCBNaWthbGFp|https://frl.publisso.de/adhoc/uri/V2VsemVsLCBNYXJpdXM=|https://frl.publisso.de/adhoc/uri/QmVpc3NlciwgRGFuaWVsYQ==|https://frl.publisso.de/adhoc/uri/QmF1ZXIsIEZyZWRlcmlj|https://frl.publisso.de/adhoc/uri/Um9obiwgQmVuamFtaW4=|https://frl.publisso.de/adhoc/uri/V2VzdGhvZmYsIFRpbW0gSC4=|https://orcid.org/0000-0002-2831-8868|https://frl.publisso.de/adhoc/uri/QmFiZWwsIE5pbmE=
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1000 Erstellt am 2023-11-18T16:21:15.831+0100
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1000 Zuletzt bearbeitet Fri Apr 05 11:43:00 CEST 2024
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