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1000 Titel
  • Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance—results from a pooled analysis of human field studies
1000 Autor/in
  1. Hahad, Omar |
  2. Schmidt, Frank P. |
  3. Hübner, Jonas |
  4. Foos, Patrick |
  5. Al-Kindi, Sadeer |
  6. Schmitt, Volker H. |
  7. Hobohm, Lukas |
  8. Keller, Karsten |
  9. Große-Dresselhaus, Christina |
  10. Schmeißer, Julian |
  11. Koppe-Schmeißer, Franziska |
  12. Vosseler, Markus |
  13. Gilan, Donya |
  14. Schulz, Andreas |
  15. Chalabi, Julian |
  16. Wild, Philipp S. |
  17. Daiber, Andreas |
  18. Herzog, Johannes |
  19. Münzel, Thomas |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-09-11
1000 Erschienen in
1000 Quellenangabe
  • 112(11):1690-1698
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00392-023-02297-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584703/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s00392-023-02297-y#Sec10 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES: A series of human field studies demonstrated that acute exposure to simulated nocturnal traffic noise is associated with cardiovascular complications and sleep disturbance, including endothelial dysfunction, increased blood pressure, and impaired sleep quality. A pooled analysis of these results remains to be established and is of tremendous interest to consolidate scientific knowledge. METHODS: We analyzed data from four randomized crossover studies (published between 2013 to 2021 and conducted at the University Medical Center Mainz, Germany). A total of 275 subjects (40.4% women, mean age 43.03 years) were each exposed to one control scenario (regular background noise) and at least to one traffic noise scenario (60 aircraft or train noise events) in their homes during nighttime. After each night, the subjects visited the study center for comprehensive cardiovascular function assessment, including the measurement of endothelial function and hemodynamic and biochemical parameters, as well as sleep-related variables. RESULTS: The pooled analysis revealed a significantly impaired endothelial function when comparing the two different noise sequences (0–60 vs. 60–0 simulated noise events, mean difference in flow-mediated dilation −2.00%, 95% CI −2.32; −1.68, p < 0.0001). In concordance, mean arterial pressure was significantly increased after traffic noise exposure (mean difference 2.50 mmHg, 95% CI 0.54; 4.45, p = 0.013). Self-reported sleep quality, the restfulness of sleep, and feeling in the morning were significantly impaired after traffic noise exposure (all p < 0.0001). DISCUSSION: Acute exposure to simulated nocturnal traffic noise is associated with endothelial dysfunction, increased mean arterial pressure, and sleep disturbance.
1000 Sacherschließung
lokal Female [MeSH]
lokal Humans
lokal Noise, Transportation/adverse effects [MeSH]
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Cardiology and Cardiovascular Medicine
lokal Adult
lokal Sleep
lokal Environmental Exposure [MeSH]
lokal Environmental Exposure
lokal Sleep [MeSH]
lokal Germany/epidemiology [MeSH]
lokal Female
lokal Germany/epidemiology
lokal General Medicine
lokal Male [MeSH]
lokal Male
lokal Hemodynamics
lokal Vascular Diseases
lokal Vascular Diseases [MeSH]
lokal Hemodynamics [MeSH]
lokal Noise, Transportation/adverse effects
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7823-7671|https://frl.publisso.de/adhoc/uri/U2NobWlkdCwgRnJhbmsgUC4=|https://frl.publisso.de/adhoc/uri/SMO8Ym5lciwgSm9uYXM=|https://frl.publisso.de/adhoc/uri/Rm9vcywgUGF0cmljaw==|https://frl.publisso.de/adhoc/uri/QWwtS2luZGksIFNhZGVlcg==|https://frl.publisso.de/adhoc/uri/U2NobWl0dCwgVm9sa2VyIEgu|https://frl.publisso.de/adhoc/uri/SG9ib2htLCBMdWthcw==|https://frl.publisso.de/adhoc/uri/S2VsbGVyLCBLYXJzdGVu|https://frl.publisso.de/adhoc/uri/R3Jvw59lLURyZXNzZWxoYXVzLCBDaHJpc3RpbmE=|https://frl.publisso.de/adhoc/uri/U2NobWVpw59lciwgSnVsaWFu|https://frl.publisso.de/adhoc/uri/S29wcGUtU2NobWVpw59lciwgRnJhbnppc2th|https://frl.publisso.de/adhoc/uri/Vm9zc2VsZXIsIE1hcmt1cw==|https://frl.publisso.de/adhoc/uri/R2lsYW4sIERvbnlh|https://frl.publisso.de/adhoc/uri/U2NodWx6LCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/Q2hhbGFiaSwgSnVsaWFu|https://frl.publisso.de/adhoc/uri/V2lsZCwgUGhpbGlwcCBTLg==|https://frl.publisso.de/adhoc/uri/RGFpYmVyLCBBbmRyZWFz|https://frl.publisso.de/adhoc/uri/SGVyem9nLCBKb2hhbm5lcw==|https://frl.publisso.de/adhoc/uri/TcO8bnplbCwgVGhvbWFz
1000 Label
1000 Förderer
  1. Projekt DEAL |
  2. Stiftung Mainzer Herz |
  3. German Heart Foundation/ German Heart Research Foundation |
1000 Fördernummer
  1. -
  2. -
  3. -
1000 Förderprogramm
  1. Open Access funding
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Stiftung Mainzer Herz |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer German Heart Foundation/ German Heart Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6472707.rdf
1000 Erstellt am 2023-12-14T08:13:00.653+0100
1000 Erstellt von 336
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1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2023-12-15T13:34:51.148+0100
1000 Objekt bearb. Fri Dec 15 13:34:19 CET 2023
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6472707 |
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