Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages

  1. Aja, Patrick Maduabuchi
  2. Ogwoni, Hilary Akobi
  3. Agu, Peter Chinedu
  4. Ekpono, Ejike Ugbala
  5. Awoke, Joshua Nonso
  6. Ukachi, Oliver Ugochukwu
  7. Orji, Obasi Uche
  8. Ale, Boniface Anthony ORCID logo
  9. Nweke, Chinonso Peter
  10. Igwenyi, Ikechukwu Okorie
  11. Alum, Esther Ugo
  12. Chukwu, Darlington C.
  13. Offor, Christian E.
  14. Asuk, Atamgba Agbor
  15. Eze, Ejike Daniel
  16. Yakubu, Ojochenemi E.
  17. Akobi, J. B.
  18. Ani, Onyedika Gabriel
  19. Awuchi, Chinaza Godswill ORCID logo

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Food Science Nutrition - 2023 - Aja - Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular.pdf 542,00KB
WeightNameValue
1000 Titel
  • Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages
1000 Autor/in
  1. Aja, Patrick Maduabuchi |
  2. Ogwoni, Hilary Akobi |
  3. Agu, Peter Chinedu |
  4. Ekpono, Ejike Ugbala |
  5. Awoke, Joshua Nonso |
  6. Ukachi, Oliver Ugochukwu |
  7. Orji, Obasi Uche |
  8. Ale, Boniface Anthony |
  9. Nweke, Chinonso Peter |
  10. Igwenyi, Ikechukwu Okorie |
  11. Alum, Esther Ugo |
  12. Chukwu, Darlington C. |
  13. Offor, Christian E. |
  14. Asuk, Atamgba Agbor |
  15. Eze, Ejike Daniel |
  16. Yakubu, Ojochenemi E. |
  17. Akobi, J. B. |
  18. Ani, Onyedika Gabriel |
  19. Awuchi, Chinaza Godswill |
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-02-07
1000 Erschienen in
1000 Quellenangabe
  • 11(6):2631-2641
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.3260 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine-disrupting chemical capable of causing male infertility. This study aimed to explore Cucumeropsis mannii seed oil effects against mitochondrial damage in rats using bisphenol A. Forty-eight rats were randomly assigned to six groups (n = 6) of eight rats each and fed the same food and water for 6 weeks. The group A rats were given 1 mL olive oil, while the ones in group B were given bisphenol A at 100 mL/kg body weight via oral route. Group C received C. mannii seed oil 7.5 mL/kg body weight C. mannii seed oil, while group D, group E, and group F were pre-administered bisphenol A at 100 mL/kg body weight, followed by treatment with C. mannii seed oil at 7.5, 5, and 2.5 mL/kg body weight, respectively. Antioxidant enzymes, glutathione, reactive oxygen species, testicular volume, malondialdehyde, body weight, and testicular studies were done using standard methods. The results of the bisphenol A-administered group showed a significant decrease in the antioxidant enzymes, glutathione, body weight, and testicular volume with elevation in the levels of reactive oxygen species, malondialdehyde, and testicular indices. BPA + CMSO-treated group showed a significant increase in GPx activity compared with BPA-exposed rats. CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, C. mannii seed oil and bisphenol A co-administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. Our findings suggest that C. mannii seed oil has considerable antioxidant potential which can be explored in therapeutic development against systemic toxicity induced by exposure to bisphenol A. Cucumeropsis mannii seed oil protects against bisphenol A-induced testicular mitochondria damages.
1000 Sacherschließung
lokal mitochondria
lokal Bisphenol A
lokal antioxidants
lokal systemic toxicity
lokal Cucumeropsis mannii
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Hinweis
  • This article also appears in: SPECIAL ISSUE: Functional Food Ingredient Preparation and Evaluation
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  1. Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages
    Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages
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