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1000
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Abstract/Summary
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Viral disinfection is important for medical facilities, the food industry, and the veterinary
field, especially in terms of controlling virus outbreaks. Therefore, standardized methods and activity
levels are available for these areas. Usually, disinfectants used in these areas are characterized by their
activity against test organisms (i.e., viruses, bacteria, and/or yeasts). This activity is usually determined
using a suspension test in which the test organism is incubated with the respective disinfectant
in solution to assess its bactericidal, yeasticidal, or virucidal activity. In addition, carrier methods that
more closely reflect real-world applications have been developed, in which microorganisms are applied
to the surface of a carrier (e.g., stainless steel frosted glass, or polyvinyl chloride (PVC)) and then
dried. However, to date, no standardized methods have become available for addressing genetically
modified vectors or disinfection-resistant oncolytic viruses such as the H1-parvovirus. Particularly,
such non-enveloped viruses, which are highly resistant to disinfectants, are not taken into account in
European standards. This article proposes a new activity claim known as “virucidal activity PLUS”,
summarizes the available methods for evaluating the virucidal activity of chemical disinfectants
against genetically modified organisms (GMOs) using current European standards, including the
activity against highly resistant parvoviridae such as the adeno-associated virus (AAV), and provides guidance on the selection of disinfectants for pharmaceutical manufacturers, laboratories, and clinical users.
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