Rapid Emergence of Appetite and Hunger Resulting in Weight Gain and Improvement of Eating Disorder Symptomatology during and after Short-Term Off-Label Metreleptin Treatment of a Patient with Anorexia Nervosa

  1. Gradl-Dietsch, Gertraud
  2. Milos, Gabriella
  3. Wabitsch, Martin
  4. Bell, Rebecca
  5. Tschöpe, Franziska
  6. Antel, Jochen ORCID logo
  7. Hebebrand, Johannes

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1000 Titel
  • Rapid Emergence of Appetite and Hunger Resulting in Weight Gain and Improvement of Eating Disorder Symptomatology during and after Short-Term Off-Label Metreleptin Treatment of a Patient with Anorexia Nervosa
1000 Autor/in
  1. Gradl-Dietsch, Gertraud |
  2. Milos, Gabriella |
  3. Wabitsch, Martin |
  4. Bell, Rebecca |
  5. Tschöpe, Franziska |
  6. Antel, Jochen |
  7. Hebebrand, Johannes |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-11-08
1000 Erschienen in
1000 Quellenangabe
  • 16(1):99-107
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1159/000527386 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889726/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Off-label treatment of a 15-year-old female patient with anorexia nervosa (AN) with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain and substantial improvement of eating disorder cognitions and of depression. The results further substantiate the effects of metreleptin on both AN and depression. We contrast these results with the widespread view that leptin is an anorexigenic hormone. Randomized controlled trials are warranted to confirm the described effects.
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Hunger
lokal Appetite [MeSH]
lokal Leptin
lokal Humans [MeSH]
lokal Starvation
lokal Weight Gain [MeSH]
lokal Anorexia Nervosa/complications [MeSH]
lokal Leptin/therapeutic use [MeSH]
lokal Hunger [MeSH]
lokal Anorexia Nervosa/drug therapy [MeSH]
lokal Anorexia nervosa
lokal Feeding and Eating Disorders [MeSH]
lokal Antidepressant
lokal Off-Label Use [MeSH]
lokal Case Report
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R3JhZGwtRGlldHNjaCwgR2VydHJhdWQ=|https://frl.publisso.de/adhoc/uri/TWlsb3MsIEdhYnJpZWxsYQ==|https://frl.publisso.de/adhoc/uri/V2FiaXRzY2gsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/QmVsbCwgUmViZWNjYQ==|https://frl.publisso.de/adhoc/uri/VHNjaMO2cGUsIEZyYW56aXNrYQ==|https://orcid.org/0000-0002-7992-5684|https://frl.publisso.de/adhoc/uri/SGViZWJyYW5kLCBKb2hhbm5lcw==
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