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WeightNameValue
1000 Titel
  • Context memory formed in medial prefrontal cortex during infancy enhances learning in adulthood
1000 Autor/in
  1. Contreras, Maria Paz |
  2. Mendez, Marta |
  3. Shan, Xia |
  4. Fechner, Julia |
  5. Sawangjit, Anuck |
  6. Born, Jan |
  7. Inostroza, Marion |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-03-20
1000 Erschienen in
1000 Quellenangabe
  • 15(1):2475
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-024-46734-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954687/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-024-46734-6#Sec25 |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Adult behavior is commonly thought to be shaped by early-life experience, although episodes experienced during infancy appear to be forgotten. Exposing male rats during infancy to discrete spatial experience we show that these rats in adulthood are significantly better at forming a spatial memory than control rats without such infantile experience. We moreover show that the adult rats' improved spatial memory capability is mainly based on memory for context information during the infantile experiences. Infantile spatial experience increased c-Fos activity at memory testing during adulthood in the prelimbic medial prefrontal cortex (mPFC), but not in the hippocampus. Inhibiting prelimbic mPFC at testing during adulthood abolished the enhancing effect of infantile spatial experience on learning. Adult spatial memory capability only benefitted from spatial experience occurring during the sensitive period of infancy, but not when occurring later during childhood, and when sleep followed the infantile experience. In conclusion, the infantile brain, by a sleep-dependent mechanism, favors consolidation of memory for the context in which episodes are experienced. These representations comprise mPFC regions and context-dependently facilitate learning in adulthood.
1000 Sacherschließung
lokal Consolidation
lokal Sleep
lokal Long-term Memory
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4296-3377|https://orcid.org/0000-0003-1718-7492|https://frl.publisso.de/adhoc/uri/U2hhbiwgWGlh|https://orcid.org/0000-0002-2959-6632|https://orcid.org/0000-0002-3432-1940|https://orcid.org/0000-0002-1847-6248|https://orcid.org/0000-0003-3483-1905
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. European Research Council |
  3. Spanish Government |
  4. China Scholarship Council |
  5. Gemeinnützige Hertie-Stiftung |
  6. Projekt DEAL |
1000 Fördernummer
  1. DFG In 279/2-1; DFG Bo854/18-1
  2. ERC AdG 883098
  3. PSI2017-83893-R
  4. 201808080042
  5. -
  6. -
1000 Förderprogramm
  1. -
  2. SleepBalance
  3. -
  4. -
  5. Hertie Network of Excellence in Clinical Neuroscience
  6. Open Access funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer DFG In 279/2-1; DFG Bo854/18-1
  2. 1000 joinedFunding-child
    1000 Förderer European Research Council |
    1000 Förderprogramm SleepBalance
    1000 Fördernummer ERC AdG 883098
  3. 1000 joinedFunding-child
    1000 Förderer Spanish Government |
    1000 Förderprogramm -
    1000 Fördernummer PSI2017-83893-R
  4. 1000 joinedFunding-child
    1000 Förderer China Scholarship Council |
    1000 Förderprogramm -
    1000 Fördernummer 201808080042
  5. 1000 joinedFunding-child
    1000 Förderer Gemeinnützige Hertie-Stiftung |
    1000 Förderprogramm Hertie Network of Excellence in Clinical Neuroscience
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6473842.rdf
1000 Erstellt am 2024-03-25T13:44:30.677+0100
1000 Erstellt von 242
1000 beschreibt frl:6473842
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2024-04-12T07:02:10.833+0200
1000 Objekt bearb. Fri Apr 12 07:01:58 CEST 2024
1000 Vgl. frl:6473842
1000 Oai Id
  1. oai:frl.publisso.de:frl:6473842 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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