Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses

  1. Foo, Isabelle Jia-Hui
  2. Chua, Brendon ORCID logo
  3. Clemens, E. Bridie
  4. Chang, So Young
  5. Jia, Xiaoxiao
  6. McQuilten, Hayley ORCID logo
  7. Yap, Ashley Huey Yiing
  8. Cabug, Aira F.
  9. Ashayeripanah, Mitra
  10. McWilliam, Hamish EG ORCID logo
  11. Villadangos, Jose ORCID logo
  12. Evrard, Maximilien
  13. Mackay, Laura ORCID logo
  14. Wakim, Linda M.
  15. Fazakerley, John ORCID logo
  16. Kedzierska, Katherine ORCID logo
  17. Kedzierski, Lukasz ORCID logo

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WeightNameValue
1000 Titel
  • Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses
1000 Autor/in
  1. Foo, Isabelle Jia-Hui |
  2. Chua, Brendon |
  3. Clemens, E. Bridie |
  4. Chang, So Young |
  5. Jia, Xiaoxiao |
  6. McQuilten, Hayley |
  7. Yap, Ashley Huey Yiing |
  8. Cabug, Aira F. |
  9. Ashayeripanah, Mitra |
  10. McWilliam, Hamish EG |
  11. Villadangos, Jose |
  12. Evrard, Maximilien |
  13. Mackay, Laura |
  14. Wakim, Linda M. |
  15. Fazakerley, John |
  16. Kedzierska, Katherine |
  17. Kedzierski, Lukasz |
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-03-23
1000 Erschienen in
1000 Quellenangabe
  • 15(1):2619
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-024-46822-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960853/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-024-46822-7#Sec28 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are highly relevant to treatment and prevention. We established a mouse model of co-infection with unrelated viruses, influenza A (IAV) and Semliki Forest virus (SFV), causing disease in different organ systems. SFV infection eight days before IAV infection results in prolonged IAV replication, elevated cytokine/chemokine levels and exacerbated lung pathology. This is associated with impaired lung IAV-specific CD8+ T cell responses, stemming from suboptimal CD8+ T cell activation and proliferation in draining lymph nodes, and dendritic cell paralysis. Prior SFV infection leads to increased blood brain barrier permeability and presence of IAV RNA in brain, associated with increased trafficking of IAV-specific CD8+ T cells and establishment of long-term tissue-resident memory. Relative to lung IAV-specific CD8+ T cells, brain memory IAV-specific CD8+ T cells have increased TCR repertoire diversity within immunodominant DbNP366+CD8+ and DbPA224+CD8+ responses, featuring suboptimal TCR clonotypes. Overall, our study demonstrates that infection with an unrelated neurotropic virus perturbs IAV-specific immune responses and exacerbates IAV disease. Our work provides key insights into therapy and vaccine regimens directed against unrelated pathogens.
1000 Sacherschließung
lokal Cellular immunity
lokal Influenza virus
lokal Viral infection
lokal Mouse
lokal Infection
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Rm9vLCBJc2FiZWxsZSBKaWEtSHVp|https://orcid.org/0000-0001-5654-1293|https://frl.publisso.de/adhoc/uri/Q2xlbWVucywgRS4gQnJpZGll|https://frl.publisso.de/adhoc/uri/Q2hhbmcsIFNvIFlvdW5n|https://frl.publisso.de/adhoc/uri/SmlhLCBYaWFveGlhbw==|https://orcid.org/0000-0002-7089-5300|https://frl.publisso.de/adhoc/uri/WWFwLCBBc2hsZXkgSHVleSBZaWluZw==|https://frl.publisso.de/adhoc/uri/Q2FidWcsIEFpcmEgRi4=|https://frl.publisso.de/adhoc/uri/QXNoYXllcmlwYW5haCwgTWl0cmE=|https://orcid.org/0000-0003-3479-3419|https://orcid.org/0000-0001-6771-8891|https://frl.publisso.de/adhoc/uri/RXZyYXJkLCBNYXhpbWlsaWVu|https://orcid.org/0000-0002-8496-6632|https://frl.publisso.de/adhoc/uri/V2FraW0sIExpbmRhIE0u|https://orcid.org/0000-0001-7071-105X|https://orcid.org/0000-0001-6141-335X|https://orcid.org/0000-0003-0203-1057
1000 Label
1000 Förderer
  1. University of Melbourne |
  2. National Health and Medical Research Council |
  3. National Health and Medical Research Council |
  4. National Health and Medical Research Council |
1000 Fördernummer
  1. -
  2. #1173871; #2016969
  3. #1163090
  4. #1154502
1000 Förderprogramm
  1. -
  2. Leadership Investigator Grant
  3. Project Grant
  4. Principal Research Fellowship
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer University of Melbourne |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer National Health and Medical Research Council |
    1000 Förderprogramm Leadership Investigator Grant
    1000 Fördernummer #1173871; #2016969
  3. 1000 joinedFunding-child
    1000 Förderer National Health and Medical Research Council |
    1000 Förderprogramm Project Grant
    1000 Fördernummer #1163090
  4. 1000 joinedFunding-child
    1000 Förderer National Health and Medical Research Council |
    1000 Förderprogramm Principal Research Fellowship
    1000 Fördernummer #1154502
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6473923.rdf
1000 Erstellt am 2024-03-27T16:01:35.773+0100
1000 Erstellt von 284
1000 beschreibt frl:6473923
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2024-04-02T09:44:03.189+0200
1000 Objekt bearb. Tue Apr 02 09:43:48 CEST 2024
1000 Vgl. frl:6473923
1000 Oai Id
  1. oai:frl.publisso.de:frl:6473923 |
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