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1000 Titel
  • Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring
1000 Autor/in
  1. Crean, Angela |
  2. Senior, Alistair |
  3. Freire, Therese |
  4. Clark, Thomas Daniel |
  5. Mackay, Flora |
  6. Austin, Gracie |
  7. Pulpitel, Tamara Jayne |
  8. Nobrega, Marcelo |
  9. BARRES, Romain |
  10. Simpson, Stephen J. |
1000 Erscheinungsjahr 2024
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2024-04-06
1000 Erschienen in
1000 Quellenangabe
  • 15(1):2982
1000 Copyrightjahr
  • 2024
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-024-46782-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998877/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-024-46782-y#Sec18 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-conception paternal dietary macronutrient balance on offspring metabolic and behavioral traits in mice. Ten isocaloric diets varying in the relative proportion of protein, fats, and carbohydrates are fed to male mice prior to mating. Dams and offspring are fed standard chow and never exposed to treatment diets. Body fat in female offspring is positively associated with the paternal consumption of fat, while in male offspring, an anxiety-like phenotype is associated to paternal diets low in protein and high in carbohydrates. Our study uncovers that the nature and the magnitude of paternal effects are driven by interactions between macronutrient balance and energy intake and are not solely the result of over- or undernutrition.
1000 Sacherschließung
lokal Epigenetic memory
lokal Metabolic syndrome
lokal Diseases
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-2605-6435|https://orcid.org/0000-0001-9805-7280|https://frl.publisso.de/adhoc/uri/RnJlaXJlLCBUaGVyZXNl|https://frl.publisso.de/adhoc/uri/Q2xhcmssIFRob21hcyBEYW5pZWw=|https://frl.publisso.de/adhoc/uri/TWFja2F5LCBGbG9yYQ==|https://frl.publisso.de/adhoc/uri/QXVzdGluLCBHcmFjaWU=|https://frl.publisso.de/adhoc/uri/UHVscGl0ZWwsIFRhbWFyYSBKYXluZQ==|https://orcid.org/0000-0002-2134-9661|https://orcid.org/0000-0002-0158-519X|https://orcid.org/0000-0003-0256-7687
1000 Label
1000 Förderer
  1. Novo Nordisk Fonden |
  2. Agence Nationale de la Recherche |
1000 Fördernummer
  1. NNF18OC0033754
  2. LABEX SIGNALIFE ANR-11-LABX-0028-01; IDEX UCAJedi ANR-15-IDEX-01
1000 Förderprogramm
  1. Challenge Programme Grant
  2. Investments for the Future
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Novo Nordisk Fonden |
    1000 Förderprogramm Challenge Programme Grant
    1000 Fördernummer NNF18OC0033754
  2. 1000 joinedFunding-child
    1000 Förderer Agence Nationale de la Recherche |
    1000 Förderprogramm Investments for the Future
    1000 Fördernummer LABEX SIGNALIFE ANR-11-LABX-0028-01; IDEX UCAJedi ANR-15-IDEX-01
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6474086.rdf
1000 Erstellt am 2024-04-08T14:06:51.046+0200
1000 Erstellt von 284
1000 beschreibt frl:6474086
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Fri Apr 12 11:42:13 CEST 2024
1000 Objekt bearb. Fri Apr 12 11:42:01 CEST 2024
1000 Vgl. frl:6474086
1000 Oai Id
  1. oai:frl.publisso.de:frl:6474086 |
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