Protein intake and type 2 diabetes mellitus: an umbrella review of systematic reviews for the evidence-based guideline for protein intake of the German Nutrition Society

  1. Schulze, Matthias B. ORCID logo
  2. Haardt, Julia ORCID logo
  3. Amini, Anna Maria ORCID logo
  4. Kalotai, Nicole
  5. Lehmann, Andreas
  6. Schmidt, Annemarie ORCID logo
  7. Buyken, Anette ORCID logo
  8. Egert, Sarah ORCID logo
  9. Ellinger, Sabine ORCID logo
  10. , Anja ORCID logo
  11. Kühn, Tilman ORCID logo
  12. Louis, Sandrine
  13. Nimptsch, Katharina ORCID logo
  14. Schwingshackl, Lukas ORCID logo
  15. Siener, Roswitha ORCID logo
  16. Zittermann, Armin ORCID logo
  17. Watzl, Bernhard ORCID logo
  18. Lorkowski, Stefan ORCID logo
  19. German Nutrition Society

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1000 Titel
  • Protein intake and type 2 diabetes mellitus: an umbrella review of systematic reviews for the evidence-based guideline for protein intake of the German Nutrition Society
1000 Autor/in
  1. Schulze, Matthias B. |
  2. Haardt, Julia |
  3. Amini, Anna Maria |
  4. Kalotai, Nicole |
  5. Lehmann, Andreas |
  6. Schmidt, Annemarie |
  7. Buyken, Anette |
  8. Egert, Sarah |
  9. Ellinger, Sabine |
  10. , Anja |
  11. Kühn, Tilman |
  12. Louis, Sandrine |
  13. Nimptsch, Katharina |
  14. Schwingshackl, Lukas |
  15. Siener, Roswitha |
  16. Zittermann, Armin |
  17. Watzl, Bernhard |
  18. Lorkowski, Stefan |
1000 Mitwirkende/r
  1. German Nutrition Society |
1000 Erscheinungsjahr 2024
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-09-17
1000 Erschienen in
1000 Quellenangabe
  • 63(1):33-50
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00394-023-03234-5 |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s00394-023-03234-5#Sec19 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • PURPOSE: Protein-rich foods show heterogeneous associations with the risk of type 2 diabetes (T2D) and it remains unclear whether habitual protein intake is related to T2D risk. We carried out an umbrella review of systematic reviews (SR) of randomised trials and/or cohort studies on protein intake in relation to risks of T2D. METHODS: Following a pre-specified protocol (PROSPERO: CRD42018082395), we retrieved SRs on protein intake and T2D risk published between July 1st 2009 and May 22nd 2022, and assessed the methodological quality and outcome-specific certainty of the evidence using a modified version of AMSTAR 2 and NutriGrade, respectively. The overall certainty of evidence was rated according to predefined criteria. RESULTS: Eight SRs were identified of which six contained meta-analyses. The majority of SRs on total protein intake had moderate or high methodological quality and moderate outcome-specific certainty of evidence according to NutriGrade, however, the latter was low for the majority of SRs on animal and plant protein. Six of the eight SRs reported risk increases with both total and animal protein. According to one SR, total protein intake in studies was ~ 21 energy percentage (%E) in the highest intake category and 15%E in the lowest intake category. Relative Risks comparing high versus low intake in most recent SRs ranged from 1.09 (two SRs, 95% CIs 1.02–1.15 and 1.06–1.13) to 1.11 (1.05–1.16) for total protein (between 8 and 12 cohort studies included) and from 1.13 (1.08–1.19) to 1.19 (two SRs, 1.11–1.28 and 1.11–1.28) (8–9 cohort studies) for animal protein. However, SRs on RCTs examining major glycaemic traits (HbA1c, fasting glucose, fasting insulin) do not support a clear biological link with T2D risk. For plant protein, some recent SRs pointed towards risk decreases and non-linear associations, however, the majority did not support an association with T2D risk. CONCLUSION: Higher total protein intake was possibly associated with higher T2D risk, while there is insufficient evidence for a risk increase with higher intakes of animal protein and a risk decrease with plant protein intake. Given that most SRs on plant protein did not indicate an association, there is possibly a lack of an effect.
1000 Sacherschließung
lokal Umbrella review
lokal Type 2 diabetes mellitus
lokal Guideline
lokal Protein
1000 Volltext
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799123/ |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-0830-5277|http://orcid.org/0000-0001-7394-4481|http://orcid.org/0000-0003-4288-1769|https://frl.publisso.de/adhoc/uri/S2Fsb3RhaSwgTmljb2xl|https://frl.publisso.de/adhoc/uri/TGVobWFubiwgQW5kcmVhcw==|http://orcid.org/0000-0003-4607-4534|http://orcid.org/0000-0002-4301-1127|http://orcid.org/0000-0003-4092-8981|http://orcid.org/0000-0002-9988-9406|http://orcid.org/0000-0002-0253-1644|http://orcid.org/0000-0001-7702-317X|https://frl.publisso.de/adhoc/uri/TG91aXMsIFNhbmRyaW5l|http://orcid.org/0000-0001-7877-205X|http://orcid.org/0000-0003-3407-7594|http://orcid.org/0000-0001-5068-6950|http://orcid.org/0000-0001-6085-6554|http://orcid.org/0000-0003-0762-7423|http://orcid.org/0000-0002-9649-840X|https://frl.publisso.de/adhoc/uri/R2VybWFuIE51dHJpdGlvbiBTb2NpZXR5
1000 Label
1000 Förderer
  1. German Federal Ministry of Food and Agriculture |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Food and Agriculture |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6475283.rdf
1000 Erstellt am 2024-04-15T14:09:52.233+0200
1000 Erstellt von 317
1000 beschreibt frl:6475283
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Apr 15 14:10:55 CEST 2024
1000 Objekt bearb. Mon Apr 15 14:10:44 CEST 2024
1000 Vgl. frl:6475283
1000 Oai Id
  1. oai:frl.publisso.de:frl:6475283 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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