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1000 Titel
  • Turquoise killifish: A natural model of age-dependent brain degeneration
1000 Autor/in
  1. de Bakker, Dennis E.M. |
  2. Valenzano, Dario R. |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-07-22
1000 Erschienen in
1000 Quellenangabe
  • 90:102019
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.arr.2023.102019 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Turquoise killifish (Nothobranchius furzeri) are naturally short-lived vertebrates that display a wide range of spontaneous age-related changes, including onset of cancer, reduced mobility, and cognitive decline. Here, we focus on describing the phenotypic spectrum of the aging killifish brain. As turquoise killifish age, their dopaminergic and noradrenergic neurons undergo a significant decline in number. Furthermore, brain aging in turquoise killifish is associated with several glial-specific changes, such as an increase in the astrocyte-covered surface area and an increase in the numbers of microglial cells, i.e. the brain-specific macrophage population. Killifish brains undergo age-dependent reduced proteasome activity and increased protein aggregation, including the aggregation of the Parkinson's disease marker α-synuclein. Parallel to brain degeneration, turquoise killifish develop spontaneous age-related gut dysbiosis, which has been proposed to affect human neurodegenerative disease. Finally, aged turquoise killifish display declined learning capacity. We argue that, taken together, the molecular, cellular and functional changes that spontaneously take place during aging in killifish brains are consistent with a robust degenerative process that shares remarkable similarities with human neurodegenerative diseases. Hence, we propose that turquoise killifish represent a powerful model of spontaneous brain degeneration which can be effectively used to explore the causal mechanisms underlying neurodegenerative diseases.
1000 Sacherschließung
lokal Fundulidae/physiology [MeSH]
lokal Humans
lokal Brain
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Aging [MeSH]
lokal Fundulidae/physiology
lokal Animals [MeSH]
lokal Brain [MeSH]
lokal Neurodegenerative Diseases [MeSH]
lokal Aging
lokal Neurodegenerative Diseases
lokal Animals
lokal Aged
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  1. https://frl.publisso.de/adhoc/uri/ZGUgQmFra2VyLCBEZW5uaXMgRS5NLg==|https://frl.publisso.de/adhoc/uri/VmFsZW56YW5vLCBEYXJpbyBSLg==
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  1. Turquoise killifish: A natural model of age-dependent brain degeneration
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1000 Erstellt am 2024-05-08T08:10:25.160+0200
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