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1000 Titel
  • Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia
1000 Autor/in
  1. Straube, Jasmin |
  2. Eifert, Theresa |
  3. Vu, Therese |
  4. Janardhanan, Yashaswini |
  5. Haldar, Rohit |
  6. von Eyss, Björn |
  7. Cooper, Leanne |
  8. Bruedigam, Claudia |
  9. Ling, Yee-May |
  10. Cooper, Emily |
  11. Patch, Ann-Marie |
  12. Bullinger, Lars |
  13. Schnoeder, Tina M. |
  14. Bywater, Megan |
  15. Heidel, Florian H. |
  16. Lane, Steven |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-02-04
1000 Erschienen in
1000 Quellenangabe
  • 37(4):741-750
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41375-023-01832-0 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079527/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Murine models offer a valuable tool to recapitulate genetically defined subtypes of AML, and to assess the potential of compound mutations and clonal evolution during disease progression. This is of particular importance for difficult to treat leukemias such as FLT3 internal tandem duplication (ITD) positive AML. While conditional gene targeting by Cre recombinase is a powerful technology that has revolutionized biomedical research, consequences of Cre expression such as lack of fidelity, toxicity or off-target effects need to be taken into consideration. We report on a transgenic murine model of FLT3-ITD induced disease, where Cre recombinase expression alone, and in the absence of a conditional allele, gives rise to an aggressive leukemia phenotype. Here, expression of various Cre recombinases leads to polyclonal expansion of FLT3
1000 Sacherschließung
lokal Mutation [MeSH]
lokal Mutation
lokal fms-Like Tyrosine Kinase 3/genetics
lokal Gene Duplication
lokal Leukemia, Myeloid, Acute/genetics
lokal Gene Duplication [MeSH]
lokal Leukemia, Myeloid, Acute/metabolism [MeSH]
lokal Animals [MeSH]
lokal Disease Models, Animal
lokal Mice
lokal Mice, Transgenic
lokal Leukemia, Myeloid, Acute/metabolism
lokal Mice, Transgenic [MeSH]
lokal Mice [MeSH]
lokal Leukemia, Myeloid, Acute/genetics [MeSH]
lokal fms-Like Tyrosine Kinase 3/genetics [MeSH]
lokal Animals
lokal Disease Models, Animal [MeSH]
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1748-0659|https://frl.publisso.de/adhoc/uri/RWlmZXJ0LCBUaGVyZXNh|https://orcid.org/0000-0003-2831-2957|https://frl.publisso.de/adhoc/uri/SmFuYXJkaGFuYW4sIFlhc2hhc3dpbmk=|https://frl.publisso.de/adhoc/uri/SGFsZGFyLCBSb2hpdA==|https://frl.publisso.de/adhoc/uri/dm9uIEV5c3MsIEJqw7Zybg==|https://frl.publisso.de/adhoc/uri/Q29vcGVyLCBMZWFubmU=|https://frl.publisso.de/adhoc/uri/QnJ1ZWRpZ2FtLCBDbGF1ZGlh|https://orcid.org/0000-0001-9757-1229|https://frl.publisso.de/adhoc/uri/Q29vcGVyLCBFbWlseQ==|https://frl.publisso.de/adhoc/uri/UGF0Y2gsIEFubi1NYXJpZQ==|https://frl.publisso.de/adhoc/uri/QnVsbGluZ2VyLCBMYXJz|https://frl.publisso.de/adhoc/uri/U2Nobm9lZGVyLCBUaW5hIE0u|https://frl.publisso.de/adhoc/uri/Qnl3YXRlciwgTWVnYW4=|https://frl.publisso.de/adhoc/uri/SGVpZGVsLCBGbG9yaWFuIEgu|https://orcid.org/0000-0002-8050-6209
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