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1000 Titel
  • Leveraging quantum computing for dynamic analyses of logical networks in systems biology
1000 Autor/in
  1. Weidner, Felix M. |
  2. Schwab, Julian D. |
  3. Wölk, Sabine |
  4. Rupprecht, Felix |
  5. Ikonomi, Nensi |
  6. Werle, Silke D. |
  7. Hoffmann, Steve |
  8. Kühl, Michael |
  9. Kestler, Hans A. |
1000 Erscheinungsjahr 2023
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-03-10
1000 Erschienen in
1000 Quellenangabe
  • 4(3):100705
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.patter.2023.100705 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028428/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The dynamics of cellular mechanisms can be investigated through the analysis of networks. One of the simplest but most popular modeling strategies involves logic-based models. However, these models still face exponential growth in simulation complexity compared with a linear increase in nodes. We transfer this modeling approach to quantum computing and use the upcoming technique in the field to simulate the resulting networks. Leveraging logic modeling in quantum computing has many benefits, including complexity reduction and quantum algorithms for systems biology tasks. To showcase the applicability of our approach to systems biology tasks, we implemented a model of mammalian cortical development. Here, we applied a quantum algorithm to estimate the tendency of the model to reach particular stable conditions and further revert dynamics. Results from two actual quantum processing units and a noisy simulator are presented, and current technical challenges are discussed.
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  1. https://frl.publisso.de/adhoc/uri/V2VpZG5lciwgRmVsaXggTS4=|https://frl.publisso.de/adhoc/uri/U2Nod2FiLCBKdWxpYW4gRC4=|https://frl.publisso.de/adhoc/uri/V8O2bGssIFNhYmluZQ==|https://frl.publisso.de/adhoc/uri/UnVwcHJlY2h0LCBGZWxpeA==|https://frl.publisso.de/adhoc/uri/SWtvbm9taSwgTmVuc2k=|https://frl.publisso.de/adhoc/uri/V2VybGUsIFNpbGtlIEQu|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFN0ZXZl|https://frl.publisso.de/adhoc/uri/S8O8aGwsIE1pY2hhZWw=|https://orcid.org/0000-0002-4759-5254
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