Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity

  1. Kim, Kyung Mok
  2. Mura-Meszaros, Anna
  3. Tollot, Marie
  4. Krishnan, Murali Shyam
  5. Jessen, Marco ORCID logo
  6. Neubert, Laura
  7. Groth, Marco ORCID logo
  8. Rodriguez-Fraticelli, Alejo ORCID logo
  9. Flohr Svendsen, Arthur ORCID logo
  10. CAMPANER, Stefano ORCID logo
  11. Andreas, Nico
  12. Kamradt, Thomas
  13. Hoffmann, Steve
  14. camargo, fernando ORCID logo
  15. Heidel, Florian ORCID logo
  16. Bystrykh, Leonid ORCID logo
  17. de Haan, Gerald ORCID logo
  18. von Eyss, Bjoern ORCID logo

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WeightNameValue
1000 Titel
  • Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity
1000 Autor/in
  1. Kim, Kyung Mok |
  2. Mura-Meszaros, Anna |
  3. Tollot, Marie |
  4. Krishnan, Murali Shyam |
  5. Jessen, Marco |
  6. Neubert, Laura |
  7. Groth, Marco |
  8. Rodriguez-Fraticelli, Alejo |
  9. Flohr Svendsen, Arthur |
  10. CAMPANER, Stefano |
  11. Andreas, Nico |
  12. Kamradt, Thomas |
  13. Hoffmann, Steve |
  14. camargo, fernando |
  15. Heidel, Florian |
  16. Bystrykh, Leonid |
  17. de Haan, Gerald |
  18. von Eyss, Bjoern |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-09-03
1000 Erschienen in
1000 Quellenangabe
  • 13(1):5187
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41467-022-32970-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440927/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-022-32970-1#Sec38 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Specific functions of the immune system are essential to protect us from infections caused by pathogens such as viruses and bacteria. However, as we age, the immune system shows a functional decline that can be attributed in large part to age-associated defects in hematopoietic stem cells (HSCs)-the cells at the apex of the immune cell hierarchy. Here, we find that the Hippo pathway coactivator TAZ is potently induced in old HSCs and protects these cells from functional decline. We identify Clca3a1 as a TAZ-induced gene that allows us to trace TAZ activity in vivo. Using CLCA3A1 as a marker, we can isolate 'young-like' HSCs from old mice. Mechanistically, Taz acts as coactivator of PU.1 and to some extent counteracts the gradual loss of PU.1 expression during HSC aging. Our work thus uncovers an essential role for Taz in a previously undescribed fail-safe mechanism in aging HSCs.
1000 Sacherschließung
lokal Hematopoietic Stem Cells/metabolism [MeSH]
lokal Mice [MeSH]
lokal Aging/physiology
lokal Hematopoietic Stem Cells/metabolism
lokal Animals
lokal Animals [MeSH]
lokal Aging/physiology [MeSH]
lokal Mice
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2ltLCBLeXVuZyBNb2s=|https://frl.publisso.de/adhoc/uri/TXVyYS1NZXN6YXJvcywgQW5uYQ==|https://frl.publisso.de/adhoc/uri/VG9sbG90LCBNYXJpZQ==|https://frl.publisso.de/adhoc/uri/S3Jpc2huYW4sIE11cmFsaSBTaHlhbQ==|https://orcid.org/0000-0001-5234-4786|https://frl.publisso.de/adhoc/uri/TmV1YmVydCwgTGF1cmE=|https://orcid.org/0000-0002-9199-8990|https://orcid.org/0000-0002-4017-8714|https://orcid.org/0000-0002-6224-2334|https://orcid.org/0000-0003-4547-6849|https://frl.publisso.de/adhoc/uri/QW5kcmVhcywgTmljbw==|https://frl.publisso.de/adhoc/uri/S2FtcmFkdCwgVGhvbWFz|https://frl.publisso.de/adhoc/uri/SG9mZm1hbm4sIFN0ZXZl|https://orcid.org/0000-0002-5630-5909|https://orcid.org/0000-0003-2438-1955|https://orcid.org/0000-0001-6924-5602|https://orcid.org/0000-0001-9706-0138|https://orcid.org/0000-0002-4731-6841
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