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1000 Titel
  • Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity
1000 Autor/in
  1. Nunna, Suneetha |
  2. Huang, Ying-Pei |
  3. Rasa, Mahdi |
  4. Krepelova, Anna |
  5. Annunziata, Francesco |
  6. Adam, Lisa |
  7. Käppel, Sandra |
  8. Hsu, Ming-Hua |
  9. neri, francesco |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-02-01
1000 Erschienen in
1000 Quellenangabe
  • 21(2):257-270
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1158/1535-7163.MCT-20-0787 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398122/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • α-Mangostin (aMan) and Paeonol (Pae) have shown anticancer and anti-inflammatory properties. However, these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as potential novel chemicals that increase cancer cell cytotoxicity over nontransformed human cells. We found that two derivative compounds, named α-Mangostin-1 (aMan1) and Paeonol-1 (Pae1) more efficiently and more specifically induced cytotoxicity in HCT116, HT29, and SW48 colorectal cancer cell lines than the parental compounds. Both aMan1 and Pae1 arrested HCT116 cells in the G
1000 Sacherschließung
lokal Acetophenones/therapeutic use [MeSH]
lokal Protein Kinase Inhibitors/pharmacology
lokal Anti-Inflammatory Agents/pharmacology
lokal Xanthones/therapeutic use [MeSH]
lokal Antineoplastic Agents/pharmacology
lokal Antineoplastic Agents/pharmacology [MeSH]
lokal Xanthones/pharmacology [MeSH]
lokal Acetophenones/therapeutic use
lokal Acetophenones/pharmacology [MeSH]
lokal Colorectal Neoplasms/drug therapy
lokal Xanthones/therapeutic use
lokal Anti-Inflammatory Agents/therapeutic use
lokal Cell Proliferation
lokal Humans
lokal Cell Proliferation [MeSH]
lokal Protein Kinase Inhibitors/pharmacology [MeSH]
lokal Humans [MeSH]
lokal Xanthones/pharmacology
lokal Colorectal Neoplasms/drug therapy [MeSH]
lokal Protein Kinase Inhibitors/therapeutic use [MeSH]
lokal Protein Kinase Inhibitors/therapeutic use
lokal Anti-Inflammatory Agents/pharmacology [MeSH]
lokal Anti-Inflammatory Agents/therapeutic use [MeSH]
lokal Antineoplastic Agents/therapeutic use [MeSH]
lokal Acetophenones/pharmacology
lokal Antineoplastic Agents/therapeutic use
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TnVubmEsIFN1bmVldGhh|https://frl.publisso.de/adhoc/uri/SHVhbmcsIFlpbmctUGVp|https://frl.publisso.de/adhoc/uri/UmFzYSwgTWFoZGk=|https://frl.publisso.de/adhoc/uri/S3JlcGVsb3ZhLCBBbm5h|https://orcid.org/0000-0001-9111-6196|https://frl.publisso.de/adhoc/uri/QWRhbSwgTGlzYQ==|https://orcid.org/0000-0001-9666-5979|https://frl.publisso.de/adhoc/uri/SHN1LCBNaW5nLUh1YQ==|https://orcid.org/0000-0003-3903-1974
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1000 Erstellt am 2024-05-08T08:35:51.349+0200
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1000 Objekt bearb. Wed May 22 14:43:53 CEST 2024
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