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1000 Titel
  • Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration
1000 Autor/in
  1. Yi, Weiwei |
  2. Zhang, Yuying |
  3. Liu, Bo |
  4. Zhou, Yuanyuan |
  5. Liao, Dandan |
  6. Qiao, Xinhua |
  7. Gao, Dan |
  8. Xie, Ting |
  9. Yao, Qin |
  10. Zhang, Yao |
  11. Qiu, Yugang |
  12. Huang, Gang |
  13. Chen, Zhiyang |
  14. Chen, Chang |
  15. Ju, Zhenyu |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-03-30
1000 Erschienen in
1000 Quellenangabe
  • 34(13):108922
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.celrep.2021.108922 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204508/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Hematopoietic stem cells (HSCs) regenerate blood cells upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) in controlling HSC regeneration is still unclear. Here, we find increased NO during HSC regeneration with an accumulation of protein aggregation. S-nitrosoglutathione reductase (GSNOR)-deleted HSCs exhibit a reduced reconstitution capacity and loss of self-renewal after chemotherapeutic injury, which is resolved by inhibition of NO synthesis. Deletion of GSNOR enhances protein S-nitrosylation, resulting in an accumulation of protein aggregation and activation of unfolded protein response (UPR). Treatment of taurocholic acid (TCA), a chemical chaperone, rescues the regeneration defect of Gsnor−/− HSCs after 5-fluorouracil (5-FU) treatment. Deletion of C/EBP homologous protein (Chop) restores the reconstitution capacity of Gsnor−/− HSCs. These findings establish a link between S-nitrosylation and protein aggregation in HSC in the context of blood regeneration.
1000 Sacherschließung
lokal Hematopoietic Stem Cells/metabolism [MeSH]
lokal Alcohol Dehydrogenase/deficiency
lokal Cell Survival [MeSH]
lokal Cell Survival
lokal Nitric Oxide/metabolism [MeSH]
lokal Alcohol Dehydrogenase/metabolism
lokal Proteostasis
lokal Protein Aggregates
lokal Regeneration
lokal Hematopoietic Stem Cells/cytology [MeSH]
lokal Phenotype [MeSH]
lokal Fluorouracil/pharmacology [MeSH]
lokal Transcription Factor CHOP/metabolism [MeSH]
lokal Gene Deletion [MeSH]
lokal Phenotype
lokal Regeneration [MeSH]
lokal Protein Aggregates [MeSH]
lokal Nitrosation
lokal Nitrosation [MeSH]
lokal Transcription Factor CHOP/metabolism
lokal Nitric Oxide/metabolism
lokal Hematopoietic Stem Cells/metabolism
lokal Alcohol Dehydrogenase/metabolism [MeSH]
lokal Proteostasis [MeSH]
lokal Fluorouracil/pharmacology
lokal Hematopoietic Stem Cells/cytology
lokal Gene Deletion
lokal Alcohol Dehydrogenase/deficiency [MeSH]
lokal Proteins/metabolism [MeSH]
lokal Proteins/metabolism
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/WWksIFdlaXdlaQ==|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFl1eWluZw==|https://frl.publisso.de/adhoc/uri/TGl1LCBCbw==|https://frl.publisso.de/adhoc/uri/WmhvdSwgWXVhbnl1YW4=|https://frl.publisso.de/adhoc/uri/TGlhbywgRGFuZGFu|https://frl.publisso.de/adhoc/uri/UWlhbywgWGluaHVh|https://frl.publisso.de/adhoc/uri/R2FvLCBEYW4=|https://frl.publisso.de/adhoc/uri/WGllLCBUaW5n|https://frl.publisso.de/adhoc/uri/WWFvLCBRaW4=|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFlhbw==|https://frl.publisso.de/adhoc/uri/UWl1LCBZdWdhbmc=|https://frl.publisso.de/adhoc/uri/SHVhbmcsIEdhbmc=|https://frl.publisso.de/adhoc/uri/Q2hlbiwgWmhpeWFuZw==|https://frl.publisso.de/adhoc/uri/Q2hlbiwgQ2hhbmc=|https://frl.publisso.de/adhoc/uri/SnUsIFpoZW55dQ==
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1000 Erstellt am 2024-05-08T09:02:46.161+0200
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