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1000 Titel
  • Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians
1000 Autor/in
  1. Iglesias, Marta |
  2. Felix, Daniel A. |
  3. Gutiérrez-Gutiérrez, Óscar |
  4. De Miguel-Bonet, Maria del Mar |
  5. Sahu, Sounak |
  6. Fernández-Varas, Beatriz |
  7. Perona, Rosario |
  8. Aboobaker, A. Aziz |
  9. Flores, Ignacio |
  10. González-Estévez, Cristina |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-07-25
1000 Erschienen in
1000 Quellenangabe
  • 13(2):405-418
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.stemcr.2019.06.005 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700675/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Reduction of caloric intake delays and prevents age-associated diseases and extends the life span in many organisms. It may be that these benefits are due to positive effects of caloric restriction on stem cell function. We use the planarian model Schmidtea mediterranea, an immortal animal that adapts to long periods of starvation by shrinking in size, to investigate the effects of starvation on telomere length. We show that the longest telomeres are a general signature of planarian adult stem cells. We also observe that starvation leads to an enrichment of stem cells with the longest telomeres and that this enrichment is dependent on mTOR signaling. We propose that one important effect of starvation for the rejuvenation of the adult stem cell pool is through increasing the median telomere length in somatic stem cells. Such a mechanism has broad implications for how dietary effects on aging are mediated at the whole-organism level.
1000 Sacherschließung
lokal Signal Transduction
lokal Helminth Proteins/genetics [MeSH]
lokal Planarians/physiology
lokal Adult Stem Cells/metabolism
lokal Planarians/genetics [MeSH]
lokal Telomere Homeostasis [MeSH]
lokal Models, Biological [MeSH]
lokal RNA Interference
lokal Argonaute Proteins/metabolism
lokal Helminth Proteins/genetics
lokal Adult Stem Cells/cytology [MeSH]
lokal Down-Regulation
lokal RNA Interference [MeSH]
lokal Argonaute Proteins/genetics
lokal Adult Stem Cells/cytology
lokal Starvation [MeSH]
lokal Telomere/genetics [MeSH]
lokal Adult Stem Cells/metabolism [MeSH]
lokal Argonaute Proteins/genetics [MeSH]
lokal Argonaute Proteins/antagonists
lokal Planarians/genetics
lokal Helminth Proteins/antagonists
lokal Helminth Proteins/metabolism
lokal Down-Regulation [MeSH]
lokal Planarians/physiology [MeSH]
lokal Telomere Homeostasis
lokal RNA, Double-Stranded/metabolism
lokal Starvation
lokal Argonaute Proteins/metabolism [MeSH]
lokal Animals [MeSH]
lokal Helminth Proteins/metabolism [MeSH]
lokal Telomere/genetics
lokal Models, Biological
lokal Signal Transduction [MeSH]
lokal RNA, Double-Stranded/metabolism [MeSH]
lokal Animals
lokal TOR Serine-Threonine Kinases/metabolism [MeSH]
lokal TOR Serine-Threonine Kinases/metabolism
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1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SWdsZXNpYXMsIE1hcnRh|https://frl.publisso.de/adhoc/uri/RmVsaXgsIERhbmllbCBBLg==|https://frl.publisso.de/adhoc/uri/R3V0acOpcnJlei1HdXRpw6lycmV6LCDDk3NjYXI=|https://frl.publisso.de/adhoc/uri/RGUgTWlndWVsLUJvbmV0LCBNYXJpYSBkZWwgTWFy|https://frl.publisso.de/adhoc/uri/U2FodSwgU291bmFr|https://frl.publisso.de/adhoc/uri/RmVybsOhbmRlei1WYXJhcywgQmVhdHJpeg==|https://frl.publisso.de/adhoc/uri/UGVyb25hLCBSb3Nhcmlv|https://frl.publisso.de/adhoc/uri/QWJvb2Jha2VyLCBBLiBBeml6|https://frl.publisso.de/adhoc/uri/RmxvcmVzLCBJZ25hY2lv|https://frl.publisso.de/adhoc/uri/R29uesOhbGV6LUVzdMOpdmV6LCBDcmlzdGluYQ==
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1000 Erstellt am 2024-05-08T10:09:26.659+0200
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1000 Zuletzt bearbeitet 2024-05-27T09:29:46.185+0200
1000 Objekt bearb. Mon May 27 09:29:36 CEST 2024
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