Download
JIN521594.pdf 2,08MB
WeightNameValue
1000 Titel
  • Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients
1000 Autor/in
  1. de Buhr, Nicole |
  2. Parplys, Ann Christin |
  3. Schroeder, Maria |
  4. Henneck, Timo |
  5. Schaumburg, Berfin |
  6. Stanelle-Bertram, Stephanie |
  7. Jarczak, Dominik |
  8. Nierhaus, Axel |
  9. Hiller, Jens |
  10. Peine, Sven |
  11. Kluge, Stefan |
  12. Klingel, Karin |
  13. Gabriel, Gülsah |
  14. von Köckritz-Blickwede, Maren |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-27
1000 Erschienen in
1000 Quellenangabe
  • 14(5):461-476
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1159/000521594 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059026/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:p>Neutrophil extracellular traps (NETs) have been described as a potential trigger of severe COVID-19. NETs are known as extracellular DNA fibers released by neutrophils in response to infection. If the host is unable to balance efficient clearance of NETs by dornases (DNases), detrimental consequences occur. Elevated levels of NETs in COVID-19 patients are associated with higher risk of morbid thrombotic complications. Here, we studied the level of NET markers and DNase activity in a cohort of COVID-19 patients compared to healthy controls. Our data confirmed an increased level of NET markers in the plasma of COVID-19 patients, with a higher level in male compared to female patients. At the same time, there was an increased DNase activity detectable in COVID-19 patients compared to healthy controls. Importantly, there was a negative correlation of DNase activity with the age of male patients. The antimicrobial peptide LL-37, which is known to stabilize NETs against DNase degradation, is embedded in NETs upon severe acute respiratory syndrome coronavirus-2-infection. The LL-37 plasma level correlates with the NET-marker level in male COVID-19 patients, indicating a potential role of LL-37 in the risk of NET-associated thrombosis in male COVID-19 patients by stabilizing NETs against DNase degradation. In conclusion, our data identify two potential risk factors of elderly male patients which may lead to inefficient NET degradation and a subsequently higher risk of NET-associated thrombosis during COVID-19: reduced DNase activity and an increased LL-37 level. </jats:p>
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Female [MeSH]
lokal LL-37
lokal Aged [MeSH]
lokal Humans [MeSH]
lokal Neutrophils/metabolism [MeSH]
lokal COVID-19
lokal Neutrophil extracellular traps
lokal Thrombosis [MeSH]
lokal Deoxyribonuclease I/metabolism [MeSH]
lokal Male [MeSH]
lokal Extracellular Traps/metabolism [MeSH]
lokal COVID-19 [MeSH]
lokal Elderly male
lokal Research Article
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4516-7838|https://frl.publisso.de/adhoc/uri/UGFycGx5cywgQW5uIENocmlzdGlu|https://orcid.org/0000-0003-1800-6462|https://frl.publisso.de/adhoc/uri/SGVubmVjaywgVGltbw==|https://frl.publisso.de/adhoc/uri/U2NoYXVtYnVyZywgQmVyZmlu|https://frl.publisso.de/adhoc/uri/U3RhbmVsbGUtQmVydHJhbSwgU3RlcGhhbmll|https://orcid.org/0000-0003-0480-2089|https://orcid.org/0000-0001-5493-7964|https://orcid.org/0000-0002-4273-8586|https://frl.publisso.de/adhoc/uri/UGVpbmUsIFN2ZW4=|https://orcid.org/0000-0001-8391-3988|https://frl.publisso.de/adhoc/uri/S2xpbmdlbCwgS2FyaW4=|https://frl.publisso.de/adhoc/uri/R2FicmllbCwgR8O8bHNhaA==|https://frl.publisso.de/adhoc/uri/dm9uIEvDtmNrcml0ei1CbGlja3dlZGUsIE1hcmVu
1000 Hinweis
  • DeepGreen-ID: 80da4752c0fd4e50b06e4c7eb2bf01f1 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6475924.rdf
1000 Erstellt am 2024-05-14T08:55:58.658+0200
1000 Erstellt von 322
1000 beschreibt frl:6475924
1000 Zuletzt bearbeitet Wed May 15 07:58:09 CEST 2024
1000 Objekt bearb. Wed May 15 07:58:09 CEST 2024
1000 Vgl. frl:6475924
1000 Oai Id
  1. oai:frl.publisso.de:frl:6475924 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source