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1000 Titel
  • Between Action and Emotional Survival During the COVID-19 era: Sensorimotor Pathways as Control Systems of Transdiagnostic Anxiety-Related Intolerance to Uncertainty
1000 Autor/in
  1. Goldstein Ferber, Sari |
  2. Shoval, Gal |
  3. Zalsman, Gil |
  4. Mikulincer, Mario |
  5. Weller, Aron |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-29
1000 Erschienen in
1000 Quellenangabe
  • 12:680403
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-31
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fpsyt.2021.680403 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358206/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:p><jats:bold>Objectives:</jats:bold> The COVID-19 pandemic and aligned social and physical distancing regulations increase the sense of uncertainty, intensifying the risk for psychopathology globally. Anxiety disorders are associated with intolerance to uncertainty. In this review we describe brain circuits and sensorimotor pathways involved in human reactions to uncertainty. We present the healthy mode of coping with uncertainty and discuss deviations from this mode.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Literature search of PubMed and Google Scholar.</jats:p><jats:p><jats:bold>Results:</jats:bold> As manifestation of anxiety disorders includes peripheral reactions and negative cognitions, we suggest an integrative model of threat cognitions modulated by sensorimotor regions: “The Sensorimotor-Cognitive-Integration-Circuit.” The model emphasizes autonomic nervous system coupling with the cortex, addressing peripheral anxious reactions to uncertainty, pathways connecting cortical regions and cost-reward evaluation circuits to sensorimotor regions, filtered by the amygdala and basal ganglia. Of special interest are the ascending and descending tracts for sensory-motor crosstalk in healthy and pathological conditions. We include arguments regarding uncertainty in anxiety reactions to the pandemic and derive from our model treatment suggestions which are supported by scientific evidence. Our model is based on systematic control theories and emphasizes the role of goal conflict regulation in health and pathology. We also address anxiety reactions as a spectrum ranging from healthy to pathological coping with uncertainty, and present this spectrum as a transdiagnostic entity in accordance with recent claims and models.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> The human need for controllability and predictability suggests that anxiety disorders reactive to the pandemic's uncertainties reflect pathological disorganization of top-down bottom-up signaling and neural noise resulting from non-pathological human needs for coherence in life.</jats:p>
1000 Sacherschließung
lokal sensorimotor
gnd 1206347392 COVID-19
lokal ascending activating system
lokal ANS
lokal Psychiatry
lokal anxiety disorders
lokal control theory
lokal descending activation
lokal COVID-19
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R29sZHN0ZWluIEZlcmJlciwgU2FyaQ==|https://frl.publisso.de/adhoc/uri/U2hvdmFsLCBHYWw=|https://frl.publisso.de/adhoc/uri/WmFsc21hbiwgR2ls|https://frl.publisso.de/adhoc/uri/TWlrdWxpbmNlciwgTWFyaW8=|https://frl.publisso.de/adhoc/uri/V2VsbGVyLCBBcm9u
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1000 Erstellt am 2024-05-14T09:07:36.845+0200
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