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1000
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Abstract/Summary
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<jats:sec><jats:title>Purpose</jats:title><jats:p>To compare survival in different strategies, preoperative systemic treatment <jats:italic>versus</jats:italic> upfront surgery, in HER2-positive early breast cancer patients in the real world.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>According to the actual upfront treatment, eligible patients from 2012 to 2015 were classified as preoperative systemic treatment or upfront surgery group prospectively. The primary endpoint is disease-free survival; the second endpoint is overall survival. All the outcomes were examined in the propensity score matching model and inverse probability of treatment weighting model.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Included in the analysis were 1,067 patients (215 in the preoperative systemic treatment group, 852 in the upfront surgery group). In the propensity score matching model (matching at 1:1 ratio), the disease-free survival of the preoperative systemic treatment group was significantly higher than that of the upfront surgery group (hazard ratio, 0.572, 95%CI, 0.371–0.881, <jats:italic>P</jats:italic>, 0.012). In the inverse probability of treatment weighting model, there was no significant difference in disease-free survival between the two groups (hazard ratio, 0.946, 95%CI, 0.763–1.172, <jats:italic>P</jats:italic>, 0.609). For overall survival, there was no significant difference between the two groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The HER2-positive patients who accepted preoperative systemic treatment had better disease-free survival than those who underwent upfront surgery by real-world statistic methods.</jats:p></jats:sec><jats:sec><jats:title>Clinical Trial Registration</jats:title><jats:p><jats:uri>Clinicaltrials.gov</jats:uri>, identifier NCT04249440.</jats:p></jats:sec>
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1000
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Hinweis
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DeepGreen-ID: d487fe37f51c41f4b5626c0f7bd2a8bf ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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