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1000 Titel
  • Comprehensive Analysis of the Expression Characteristics of the Enhancer of the Zeste Homolog 2 Gene in Pan-Cancer
1000 Autor/in
  1. Kang, Yuanyuan |
  2. Zhang, Ying |
  3. Sun, Yan |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-26
1000 Erschienen in
1000 Quellenangabe
  • 12:658241
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-28
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fgene.2021.658241 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350738/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:p>Although more and more studies have shown that EZH2 was closely related to human cancer, no pan-cancer analysis is available. Therefore, we summarized and analyzed the potential carcinogenic effect of EZH2 for the first time based on TCGA (cancer genome map) datasets. EZH2 is expressed highly in most tumors and there is a significant correlation between the EZH2 expression and the prognosis of patients. We observed the increased phosphorylation levels of T487 in breast cancer, colon cancer, UCEC, and LUAD. The expression of EZH2 was associated with the CD8+, tregs, macrophage, and cancer-associated fibroblast infiltration in some tumors. In addition, the cell cycle and cellular biology were involved in the functional mechanisms of EZH2. Our study summarized and analyzed the carcinogenic effect of EZH2 in different tumors comprehensively and provided a theoretical basis for targeting EZH2 therapy.</jats:p>
1000 Sacherschließung
lokal TCGA
lokal Genetics
lokal disease-free survival
lokal GEO
lokal EZH2
lokal overall survival
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2FuZywgWXVhbnl1YW4=|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFlpbmc=|https://frl.publisso.de/adhoc/uri/U3VuLCBZYW4=
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1000 Label
1000 Förderer
  1. Foundation for Innovative Research Groups of the National Natural Science Foundation of China |
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  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Foundation for Innovative Research Groups of the National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 Erstellt am 2024-05-14T10:07:55.545+0200
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1000 Zuletzt bearbeitet 2024-05-15T09:06:04.714+0200
1000 Objekt bearb. Wed May 15 09:06:04 CEST 2024
1000 Vgl. frl:6476124
1000 Oai Id
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