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10.1186_s40463-022-00573-x.pdf 1,10MB
WeightNameValue
1000 Titel
  • Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma
1000 Autor/in
  1. Tsai, Ming-Hsien |
  2. Chuang, Hui-Ching |
  3. Lin, Yu-Tsai |
  4. Huang, Tai-Lin |
  5. Fang, Fu-Min |
  6. Lu, Hui |
  7. Chien, Chih-Yen |
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-01
1000 Erschienen in
1000 Quellenangabe
  • 51(1):18
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40463-022-00573-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052608/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Oral cancer with pT1-3N1 without extracapsular extension of the lymph node is classified as stage III according to the eighth edition of the AJCC staging system. Outcomes of a subgroup of patients classified as having stage III oral cancer with single nodal metastasis are observed to be various clinically. Therefore, such clinical outcomes for subgroup analyses in this cohort are necessary. </jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Patients with pT1-3N1 (based on the eighth edition of the AJCC staging system) oral cancer who underwent surgery between 2007 and 2016 were enrolled retrospectively for survival analyses.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>A total of 105 patients—including 28 patients with pT1N1 disease and 77 patients with pT2-3N1 disease—participated in the study. Pathological T classification was the only statistically significant prognosticator according to univariate analysis. The patients with pT1N1 disease showed better 5-year overall survival (OS), disease specific survival (DSS), and disease free survival (DFS) than those with pT2-3N1 disease (pT1N1 vs pT2-3N1, OS: 96.4% vs 72.2%, <jats:italic>p</jats:italic> = 0.004; DSS: 96.4% vs 77.3%, <jats:italic>p</jats:italic> = 0.021; DFS: 84.6% vs 62.3%, <jats:italic>p</jats:italic> = 0.023). Besides, there was no potential clinicopathological confounder which is significant associated with different pathological T classifications in this unique cohort.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Patients in the pT1N1 subgroup have significantly favorable prognosis than those with pT2-3N1 disease. Down-staging and reclassifying pT1N1 subgroup patients with oral cancer may be considered in tumor staging.</jats:p> </jats:sec><jats:sec> <jats:title>Graphical Abstract</jats:title> </jats:sec>
1000 Sacherschließung
lokal Mouth Neoplasms/pathology [MeSH]
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal N1
lokal Prognosis
lokal Squamous Cell Carcinoma of Head and Neck [MeSH]
lokal Mouth Neoplasms/surgery [MeSH]
lokal Head and Neck Neoplasms [MeSH]
lokal Prognosis [MeSH]
lokal Carcinoma, Squamous Cell/pathology [MeSH]
lokal Original Research Article
lokal Oral cancer
lokal Single nodal metastasis
lokal Stage III
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VHNhaSwgTWluZy1Ic2llbg==|https://frl.publisso.de/adhoc/uri/Q2h1YW5nLCBIdWktQ2hpbmc=|https://frl.publisso.de/adhoc/uri/TGluLCBZdS1Uc2Fp|https://frl.publisso.de/adhoc/uri/SHVhbmcsIFRhaS1MaW4=|https://frl.publisso.de/adhoc/uri/RmFuZywgRnUtTWlu|https://frl.publisso.de/adhoc/uri/THUsIEh1aQ==|https://orcid.org/0000-0002-6690-6038
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1000 Erstellt am 2024-05-14T11:08:49.008+0200
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