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1000 Titel
  • Association Between Insulin Resistance and Remote Diffusion-Weighted Imaging Lesions in Primary Intracerebral Hemorrhage
1000 Autor/in
  1. Ye, Xiang-hua |
  2. Zhang, Jian-li |
  3. Jin, Yu-jia |
  4. Shen, Dan |
  5. Hao, Xiao-di |
  6. Li, Jia-wen |
  7. Zhong, Jia-wei |
  8. Jin, Lu-hang |
  9. Tong, Lu-sha |
  10. Gao, Feng |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-29
1000 Erschienen in
1000 Quellenangabe
  • 12:719462
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-31
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2021.719462 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358397/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:sec><jats:title>Background</jats:title><jats:p>Abnormal glucose metabolism was shown to be associated with the occurrence of remote diffusion-weighted imaging lesions (R-DWILs) after primary intracerebral hemorrhage (ICH) onset. Insulin resistance is a metabolic disorder that was regarded as an indicator of chronic systemic inflammation. In this study, we aimed to determine the effect of insulin resistance on the occurrence of R-DWILs in ICH.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with primary ICH within 14 days after onset were prospectively enrolled from November 2017 to October 2019. R-DWILs was defined as remote focal hyperintensity from the hematoma in DWI, with corresponding hypointensity in apparent diffusion coefficient. The homeostasis model assessment of insulin resistance (HOMA-IR) was used for insulin resistance estimation and calculated as fasting insulin (μU/ml) × fasting glucose (mmol/L)/22.5. Patients in our cohort were divided into four groups according to HOMA-IR index quartiles. Logistic regression analysis and smoothing plots were used to evaluate the association of HOMA-IR with R-DWIL occurrence<jats:strike>.</jats:strike> Sensitivity analysis was performed in non-diabetic patients, non-obese patients, hypertensive ICH patients, and patients 60 years and older separately. The association between HOMA-IR and systemic inflammatory immune indices neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) was examined with multiple linear regression analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among the 345 patients, 54 (15.7%) had R-DWILs<jats:strike>. </jats:strike>Both the third and fourth quartiles of HOMA-IR index were robustly associated with an increased risk of R-DWIL occurrence (adjusted OR 3.58, 95% CI 1.33-9.65; adjusted OR 3.91, 95%CI 1.47-10.41) when compared with the first quartile. The association was consistent in non-diabetic, non-obese, hypertensive ICH patients, as well as in patients 60 years and older. Furthermore, both NLR and MLR were independently associated with HOMA-IR.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our study suggested that insulin resistance evaluated with HOMA-IR index was independently associated with the presence of R-DWILs in patients with acute and subacute primary ICH. It may provide new insights into the metabolism-related brain injury after ICH ictus.</jats:p></jats:sec>
1000 Sacherschließung
lokal Insulin/blood [MeSH]
lokal Female [MeSH]
lokal Immunology
lokal Aged [MeSH]
lokal Diffusion Magnetic Resonance Imaging/methods [MeSH]
lokal Humans [MeSH]
lokal Cerebrovascular Disorders/complications [MeSH]
lokal Inflammation Mediators/metabolism [MeSH]
lokal insulin resistance
lokal Cerebral Hemorrhage/etiology [MeSH]
lokal Middle Aged [MeSH]
lokal Disease Susceptibility [MeSH]
lokal Cerebral Hemorrhage/metabolism [MeSH]
lokal Disease Management [MeSH]
lokal intracerebral hemorrhage
lokal metabolism
lokal Male [MeSH]
lokal Blood Glucose [MeSH]
lokal Insulin Resistance [MeSH]
lokal Image Processing, Computer-Assisted [MeSH]
lokal Cerebral Hemorrhage/diagnostic imaging [MeSH]
lokal inflammation
lokal remote diffusion-weighted imaging lesions
lokal Biomarkers [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/WWUsIFhpYW5nLWh1YQ==|https://frl.publisso.de/adhoc/uri/WmhhbmcsIEppYW4tbGk=|https://frl.publisso.de/adhoc/uri/SmluLCBZdS1qaWE=|https://frl.publisso.de/adhoc/uri/U2hlbiwgRGFu|https://frl.publisso.de/adhoc/uri/SGFvLCBYaWFvLWRp|https://frl.publisso.de/adhoc/uri/TGksIEppYS13ZW4=|https://frl.publisso.de/adhoc/uri/WmhvbmcsIEppYS13ZWk=|https://frl.publisso.de/adhoc/uri/SmluLCBMdS1oYW5n|https://frl.publisso.de/adhoc/uri/VG9uZywgTHUtc2hh|https://frl.publisso.de/adhoc/uri/R2FvLCBGZW5n
1000 Hinweis
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1000 Erstellt am 2024-05-14T11:41:26.892+0200
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1000 Zuletzt bearbeitet 2024-05-15T10:31:25.156+0200
1000 Objekt bearb. Wed May 15 10:31:25 CEST 2024
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