Bringing Greater Accuracy to Europe’s Healthcare Systems: The Unexploited Potential of Biomarker Testing in Oncology

  1. Horgan, Denis
  2. Ciliberto, Gennaro
  3. Conte, Pierfranco
  4. Baldwin, David
  5. Seijo, Luis
  6. Montuenga, Luis M.
  7. Paz-Ares, Luis
  8. Garassino, Marina
  9. Penault-Llorca, Frederique
  10. Galli, Fabrizia
  11. Ray-Coquard, Isabelle
  12. Querleu, Denis
  13. Capoluongo, Ettore
  14. Banerjee, Susana
  15. Riegman, Peter
  16. Kerr, Keith
  17. Horbach, Benjamin
  18. Büttner, Reinhard
  19. Van Poppel, Hein
  20. Bjartell, Anders
  21. Codacci-Pisanelli, Giovanni ORCID logo
  22. Westphalen, Benedikt
  23. Calvo, Fabien
  24. Koeva-Balabanova, Jasmina
  25. Hall, Stephen
  26. Paradiso, Angelo
  27. Kalra, Dipak
  28. Cobbaert, Christa ORCID logo
  29. Varea Menendez, Rocio
  30. Maravic, Zorana
  31. Fotaki, Vassiliki ORCID logo
  32. Bennouna, Jaafar
  33. Cauchin, Estelle
  34. Malats, Nuria ORCID logo
  35. Gutiérrez-Ibarluzea, Iñaki
  36. Gannon, Benjamin
  37. Mastris, Ken
  38. Bernini, Chiara
  39. Gallagher, William
  40. Buglioni, Simonetta
  41. Kent, Alastair
  42. Munzone, Elisabetta
  43. Belina, Ivica
  44. Van Meerbeeck, Jan
  45. Duffy, Michael
  46. Sarnowska, Elżbieta
  47. Jagielska, Beata
  48. Mee, Sarah
  49. Curigliano, Giuseppe

Download
BMH511209.pdf 1,52MB
WeightNameValue
1000 Titel
  • Bringing Greater Accuracy to Europe’s Healthcare Systems: The Unexploited Potential of Biomarker Testing in Oncology
1000 Autor/in
  1. Horgan, Denis |
  2. Ciliberto, Gennaro |
  3. Conte, Pierfranco |
  4. Baldwin, David |
  5. Seijo, Luis |
  6. Montuenga, Luis M. |
  7. Paz-Ares, Luis |
  8. Garassino, Marina |
  9. Penault-Llorca, Frederique |
  10. Galli, Fabrizia |
  11. Ray-Coquard, Isabelle |
  12. Querleu, Denis |
  13. Capoluongo, Ettore |
  14. Banerjee, Susana |
  15. Riegman, Peter |
  16. Kerr, Keith |
  17. Horbach, Benjamin |
  18. Büttner, Reinhard |
  19. Van Poppel, Hein |
  20. Bjartell, Anders |
  21. Codacci-Pisanelli, Giovanni |
  22. Westphalen, Benedikt |
  23. Calvo, Fabien |
  24. Koeva-Balabanova, Jasmina |
  25. Hall, Stephen |
  26. Paradiso, Angelo |
  27. Kalra, Dipak |
  28. Cobbaert, Christa |
  29. Varea Menendez, Rocio |
  30. Maravic, Zorana |
  31. Fotaki, Vassiliki |
  32. Bennouna, Jaafar |
  33. Cauchin, Estelle |
  34. Malats, Nuria |
  35. Gutiérrez-Ibarluzea, Iñaki |
  36. Gannon, Benjamin |
  37. Mastris, Ken |
  38. Bernini, Chiara |
  39. Gallagher, William |
  40. Buglioni, Simonetta |
  41. Kent, Alastair |
  42. Munzone, Elisabetta |
  43. Belina, Ivica |
  44. Van Meerbeeck, Jan |
  45. Duffy, Michael |
  46. Sarnowska, Elżbieta |
  47. Jagielska, Beata |
  48. Mee, Sarah |
  49. Curigliano, Giuseppe |
1000 Verlag
  • S. Karger AG
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-14
1000 Erschienen in
1000 Quellenangabe
  • 5(3)
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1159/000511209 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841733/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:p>Rapid and continuing advances in biomarker testing are not being matched by take-up in health systems, and this is hampering both patient care and innovation. It also risks costing health systems the opportunity to make their services more efficient and, over time, more economical. This paper sets out the potential of biomarker testing, the unfolding precision and range of possible diagnosis and prediction, and the many obstacles to adoption. It offers case studies of biomarker testing in breast, ovarian, prostate, lung, thyroid and colon cancers, and derives specific lessons as to the potential and actual use of each of them. It also draws lessons about how to improve access and alignment, and to remedy the data deficiencies that impede development. And it suggests solutions to outstanding issues – notably including funding and the tangled web of obtaining reimbursement or equivalent coverage that Europe’s fragmented health system implies. It urges a European evolution towards an initial minimum testing scenario, which would guarantee universal access to a suite of biomarker tests for the currently most common conditions, and, further into the future, to an optimum testing scenario in which a much wider range of biomarker tests would be introduced and become part of a more sophisticated health system articulated around personalised medicine. For exploiting genomics to the full, it argues the need for a new policy framework for Europe. Biomarker testing is not an issue that can be treated in isolation, since the purpose of testing is to improve health. Its use is therefore always closely linked to specific health challenges and needs to be viewed in the broader policy context in the EU and more widely. The paper is the result of extensive engagement with experts and decision makers to develop the framework, and consequently represents a wide consensus of views on how healthcare systems should respond from push and pull factors at local, national and cross-border and EU level. It contains strong views and clear recommendations springing from the convictions of patients, clinicians, academics, medicines authorities, HTA bodies, payers, the diagnostic, pharmaceutical and ICT industries, and national policy makers. </jats:p>
1000 Sacherschließung
lokal Biomarkers
lokal Molecular diagnostics
lokal Public health
lokal Cancer plan
lokal Companion diagnostics
lokal Personalised healthcare
lokal Reimbursement challenges
lokal Million European Genome
lokal Comprehensive genomic profiling
lokal Position Statement
lokal Diagnostic tests
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SG9yZ2FuLCBEZW5pcw==|https://frl.publisso.de/adhoc/uri/Q2lsaWJlcnRvLCBHZW5uYXJv|https://frl.publisso.de/adhoc/uri/Q29udGUsIFBpZXJmcmFuY28=|https://frl.publisso.de/adhoc/uri/QmFsZHdpbiwgRGF2aWQ=|https://frl.publisso.de/adhoc/uri/U2Vpam8sIEx1aXM=|https://frl.publisso.de/adhoc/uri/TW9udHVlbmdhLCBMdWlzwqBNLg==|https://frl.publisso.de/adhoc/uri/UGF6LUFyZXMsIEx1aXM=|https://frl.publisso.de/adhoc/uri/R2FyYXNzaW5vLCBNYXJpbmE=|https://frl.publisso.de/adhoc/uri/UGVuYXVsdC1MbG9yY2EsIEZyZWRlcmlxdWU=|https://frl.publisso.de/adhoc/uri/R2FsbGksIEZhYnJpemlh|https://frl.publisso.de/adhoc/uri/UmF5LUNvcXVhcmQsIElzYWJlbGxl|https://frl.publisso.de/adhoc/uri/UXVlcmxldSwgRGVuaXM=|https://frl.publisso.de/adhoc/uri/Q2Fwb2x1b25nbywgRXR0b3Jl|https://frl.publisso.de/adhoc/uri/QmFuZXJqZWUsIFN1c2FuYQ==|https://frl.publisso.de/adhoc/uri/UmllZ21hbiwgUGV0ZXI=|https://frl.publisso.de/adhoc/uri/S2VyciwgS2VpdGg=|https://frl.publisso.de/adhoc/uri/SG9yYmFjaCwgQmVuamFtaW4=|https://frl.publisso.de/adhoc/uri/QsO8dHRuZXIsIFJlaW5oYXJk|https://frl.publisso.de/adhoc/uri/VmFuwqBQb3BwZWwsIEhlaW4=|https://frl.publisso.de/adhoc/uri/QmphcnRlbGwsIEFuZGVycw==|https://orcid.org/0000-0003-4662-7944|https://frl.publisso.de/adhoc/uri/V2VzdHBoYWxlbiwgQmVuZWRpa3Q=|https://frl.publisso.de/adhoc/uri/Q2Fsdm8sIEZhYmllbg==|https://frl.publisso.de/adhoc/uri/S29ldmEtQmFsYWJhbm92YSwgSmFzbWluYQ==|https://frl.publisso.de/adhoc/uri/SGFsbCwgU3RlcGhlbg==|https://frl.publisso.de/adhoc/uri/UGFyYWRpc28sIEFuZ2Vsbw==|https://frl.publisso.de/adhoc/uri/S2FscmEsIERpcGFr|https://orcid.org/0000-0003-3565-1404|https://frl.publisso.de/adhoc/uri/VmFyZWHCoE1lbmVuZGV6LCBSb2Npbw==|https://frl.publisso.de/adhoc/uri/TWFyYXZpYywgWm9yYW5h|https://orcid.org/0000-0001-9112-3257|https://frl.publisso.de/adhoc/uri/QmVubm91bmEsIEphYWZhcg==|https://frl.publisso.de/adhoc/uri/Q2F1Y2hpbiwgRXN0ZWxsZQ==|https://orcid.org/0000-0003-2538-3784|https://frl.publisso.de/adhoc/uri/R3V0acOpcnJlei1JYmFybHV6ZWEsIEnDsWFraQ==|https://frl.publisso.de/adhoc/uri/R2Fubm9uLCBCZW5qYW1pbg==|https://frl.publisso.de/adhoc/uri/TWFzdHJpcywgS2Vu|https://frl.publisso.de/adhoc/uri/QmVybmluaSwgQ2hpYXJh|https://frl.publisso.de/adhoc/uri/R2FsbGFnaGVyLCBXaWxsaWFt|https://frl.publisso.de/adhoc/uri/QnVnbGlvbmksIFNpbW9uZXR0YQ==|https://frl.publisso.de/adhoc/uri/S2VudCwgQWxhc3RhaXI=|https://frl.publisso.de/adhoc/uri/TXVuem9uZSwgRWxpc2FiZXR0YQ==|https://frl.publisso.de/adhoc/uri/QmVsaW5hLCBJdmljYQ==|https://frl.publisso.de/adhoc/uri/VmFuwqBNZWVyYmVlY2ssIEphbg==|https://frl.publisso.de/adhoc/uri/RHVmZnksIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/U2Fybm93c2thLCBFbMW8YmlldGE=|https://frl.publisso.de/adhoc/uri/SmFnaWVsc2thLCBCZWF0YQ==|https://frl.publisso.de/adhoc/uri/TWVlLCBTYXJhaA==|https://frl.publisso.de/adhoc/uri/Q3VyaWdsaWFubywgR2l1c2VwcGU=
1000 Hinweis
  • DeepGreen-ID: 47e0aeac475d459a8cec8dbf7221b55f ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6477137.rdf
1000 Erstellt am 2024-05-17T11:24:42.871+0200
1000 Erstellt von 322
1000 beschreibt frl:6477137
1000 Zuletzt bearbeitet 2024-05-17T15:09:36.202+0200
1000 Objekt bearb. Fri May 17 15:09:36 CEST 2024
1000 Vgl. frl:6477137
1000 Oai Id
  1. oai:frl.publisso.de:frl:6477137 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source