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1000 Titel
  • Sensorimotor Integration in Childhood Dystonia and Dystonic Cerebral Palsy—A Developmental Perspective
1000 Autor/in
  1. McClelland, Verity M. |
  2. Lin, Jean-Pierre |
1000 Verlag
  • Frontiers Media S.A.
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-23
1000 Erschienen in
1000 Quellenangabe
  • 12:668081
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-25
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fneur.2021.668081 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343097/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:p>Dystonia is a disorder of sensorimotor integration, involving dysfunction within the basal ganglia, cortex, cerebellum, or their inter-connections as part of the sensorimotor network. Some forms of dystonia are also characterized by maladaptive or exaggerated plasticity. Development of the neuronal processes underlying sensorimotor integration is incompletely understood but involves activity-dependent modeling and refining of sensorimotor circuits through processes that are already taking place <jats:italic>in utero</jats:italic> and which continue through infancy, childhood, and into adolescence. Several genetic dystonias have clinical onset in early childhood, but there is evidence that sensorimotor circuit development may already be disrupted prenatally in these conditions. Dystonic cerebral palsy (DCP) is a form of acquired dystonia with perinatal onset during a period of rapid neurodevelopment and activity-dependent refinement of sensorimotor networks. However, physiological studies of children with dystonia are sparse. This discussion paper addresses the role of neuroplasticity in the development of sensorimotor integration with particular focus on the relevance of these mechanisms for understanding childhood dystonia, DCP, and implications for therapy selection, including neuromodulation and timing of intervention.</jats:p>
1000 Sacherschließung
lokal Neurology
lokal neurodevelopment
lokal children
lokal dystonic cerebral palsy
lokal neuromodulation
lokal sensorimotor integration
lokal plasticity
lokal dystonia
lokal critical windows
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWNDbGVsbGFuZCwgVmVyaXR5IE0u|https://frl.publisso.de/adhoc/uri/TGluLCBKZWFuLVBpZXJyZQ==
1000 Hinweis
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1000 Label
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  1. Medical Research Council |
  2. Rosetrees Trust |
  3. Action Medical Research |
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1000 Dateien
1000 Förderung
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    1000 Förderer Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer -
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    1000 Förderer Rosetrees Trust |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Action Medical Research |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 Erstellt am 2024-05-17T11:37:21.234+0200
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1000 Zuletzt bearbeitet 2024-05-17T14:31:53.230+0200
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