Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study

  1. D’Aquila, Patrizia
  2. Giacconi, Robertina
  3. Malavolta, Marco
  4. Piacenza, Francesco
  5. Bürkle, Alexander
  6. Villanueva, María Moreno
  7. Dollé, Martijn E. T.
  8. Jansen, Eugène
  9. Grune, Tilman
  10. Gonos, Efstathios S.
  11. Franceschi, Claudio
  12. Capri, Miriam
  13. Grubeck-Loebenstein, Beatrix
  14. Sikora, Ewa
  15. Toussaint, Olivier
  16. Debacq-Chainiaux, Florence
  17. Hervonen, Antti
  18. Hurme, Mikko
  19. Slagboom, P. Eline
  20. Schön, Christiane
  21. Bernhardt, Jürgen
  22. Breusing, Nicolle
  23. Passarino, Giuseppe
  24. Provinciali, Mauro
  25. Bellizzi, Dina

Download
fmicb-12-707515.pdf 700,95KB
WeightNameValue
1000 Titel
  • Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study
1000 Autor/in
  1. D’Aquila, Patrizia |
  2. Giacconi, Robertina |
  3. Malavolta, Marco |
  4. Piacenza, Francesco |
  5. Bürkle, Alexander |
  6. Villanueva, María Moreno |
  7. Dollé, Martijn E. T. |
  8. Jansen, Eugène |
  9. Grune, Tilman |
  10. Gonos, Efstathios S. |
  11. Franceschi, Claudio |
  12. Capri, Miriam |
  13. Grubeck-Loebenstein, Beatrix |
  14. Sikora, Ewa |
  15. Toussaint, Olivier |
  16. Debacq-Chainiaux, Florence |
  17. Hervonen, Antti |
  18. Hurme, Mikko |
  19. Slagboom, P. Eline |
  20. Schön, Christiane |
  21. Bernhardt, Jürgen |
  22. Breusing, Nicolle |
  23. Passarino, Giuseppe |
  24. Provinciali, Mauro |
  25. Bellizzi, Dina |
1000 Verlag
  • Frontiers Media S.A.
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-26
1000 Erschienen in
1000 Quellenangabe
  • 12:707515
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-28
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fmicb.2021.707515 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350766/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:p>The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and function remain to be elucidated. This study aimed to investigate the presence of blood microbiome by quantitative real-time PCRs targeting the 16S rRNA gene. To our knowledge, this is the first study in which the circulating microbiome has been analyzed in such a large sample of individuals since the study was carried out on 1285 Randomly recruited Age-Stratified Individuals from the General population (RASIG). The samples came from several different European countries recruited within the EU Project MARK-AGE in which a series of clinical biochemical parameters were determined. The results obtained reveal an association between microbial DNA copy number and geographic origin. By contrast, no gender and age-related difference emerged, thus demonstrating the role of the environment in influencing the above levels independent of age and gender at least until the age of 75. In addition, a significant positive association was found with Free Fatty Acids (FFA) levels, leukocyte count, insulin, and glucose levels. Since these factors play an essential role in both health and disease conditions, their association with the extent of the blood microbiome leads us to consider the blood microbiome as a potential biomarker of human health.</jats:p>
1000 Sacherschließung
lokal geographic origin
lokal insulin
lokal leukocytes
lokal 16S rRNA gene
lokal glucose
lokal free fatty acids
lokal Microbiology
lokal aging
lokal blood microbiome
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/ROKAmUFxdWlsYSwgUGF0cml6aWE=|https://frl.publisso.de/adhoc/uri/R2lhY2NvbmksIFJvYmVydGluYQ==|https://frl.publisso.de/adhoc/uri/TWFsYXZvbHRhLCBNYXJjbw==|https://frl.publisso.de/adhoc/uri/UGlhY2VuemEsIEZyYW5jZXNjbw==|https://frl.publisso.de/adhoc/uri/QsO8cmtsZSwgQWxleGFuZGVy|https://frl.publisso.de/adhoc/uri/VmlsbGFudWV2YSwgTWFyw61hIE1vcmVubw==|https://frl.publisso.de/adhoc/uri/RG9sbMOpLCBNYXJ0aWpuIEUuIFQu|https://frl.publisso.de/adhoc/uri/SmFuc2VuLCBFdWfDqG5l|https://frl.publisso.de/adhoc/uri/R3J1bmUsIFRpbG1hbg==|https://frl.publisso.de/adhoc/uri/R29ub3MsIEVmc3RhdGhpb3MgUy4=|https://frl.publisso.de/adhoc/uri/RnJhbmNlc2NoaSwgQ2xhdWRpbw==|https://frl.publisso.de/adhoc/uri/Q2FwcmksIE1pcmlhbQ==|https://frl.publisso.de/adhoc/uri/R3J1YmVjay1Mb2ViZW5zdGVpbiwgQmVhdHJpeA==|https://frl.publisso.de/adhoc/uri/U2lrb3JhLCBFd2E=|https://frl.publisso.de/adhoc/uri/VG91c3NhaW50LCBPbGl2aWVy|https://frl.publisso.de/adhoc/uri/RGViYWNxLUNoYWluaWF1eCwgRmxvcmVuY2U=|https://frl.publisso.de/adhoc/uri/SGVydm9uZW4sIEFudHRp|https://frl.publisso.de/adhoc/uri/SHVybWUsIE1pa2tv|https://frl.publisso.de/adhoc/uri/U2xhZ2Jvb20sIFAuIEVsaW5l|https://frl.publisso.de/adhoc/uri/U2Now7ZuLCBDaHJpc3RpYW5l|https://frl.publisso.de/adhoc/uri/QmVybmhhcmR0LCBKw7xyZ2Vu|https://frl.publisso.de/adhoc/uri/QnJldXNpbmcsIE5pY29sbGU=|https://frl.publisso.de/adhoc/uri/UGFzc2FyaW5vLCBHaXVzZXBwZQ==|https://frl.publisso.de/adhoc/uri/UHJvdmluY2lhbGksIE1hdXJv|https://frl.publisso.de/adhoc/uri/QmVsbGl6emksIERpbmE=
1000 Hinweis
  • DeepGreen-ID: 5d0f23aa94ef4285bbb84ba5273346c3 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6477253.rdf
1000 Erstellt am 2024-05-17T12:09:46.332+0200
1000 Erstellt von 322
1000 beschreibt frl:6477253
1000 Zuletzt bearbeitet 2024-05-17T14:44:36.874+0200
1000 Objekt bearb. Fri May 17 14:44:36 CEST 2024
1000 Vgl. frl:6477253
1000 Oai Id
  1. oai:frl.publisso.de:frl:6477253 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source