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1000
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Abstract/Summary
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<jats:sec><jats:title>Introduction</jats:title><jats:p>Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objective of this study was to investigate the safety and potential therapeutic effects of exercise in c-TA.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This was a 12-week, multicenter, randomized, controlled trial, to test the effects of a home-based, exercise intervention <jats:italic>vs</jats:italic>. standard of care in c-TA patients in remission. The primary outcomes were arterial inflammation, assessed by [<jats:sup>18</jats:sup>F] FDG- PET/MRI and systemic inflammatory markers. Secondary outcomes included, physical activity levels, functionality, body composition, disease-related parameters, and quality of life.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Thirty-seven patients were assessed for eligibility, which represents the total number of c-TA patients being followed by the three specialized medical ambulatory services in Sao Paulo. After exclusions, fourteen c-TA patients (71.4% females) aged 12-25 years were randomly allocated into exercised (n=5) and non-exercised groups (n=9). Exercise did not exacerbate arterial inflammation. In fact, exercised patients had a reduction in the frequency of vessel segments with severe inflammation, whereas the non-exercised patients had an opposite response (<jats:italic>P</jats:italic>=0.007). Greater improvements in visceral fat, steps per day, functionality and physical component SF-36 were observed in the exercised patients (<jats:italic>P ≤</jats:italic> 0.05).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in c-TA patients. Thus, exercise arises as a novel, evidence-based intervention to improve general health in c-TA.</jats:p></jats:sec><jats:sec><jats:title>Clinical Trial Registration</jats:title><jats:p><jats:uri>https://www.clinicaltrials.gov/ct2/show/NCT03494062?term=NCT03494062&amp;draw=2&amp;rank=1</jats:uri>, identifier NCT03494062.</jats:p></jats:sec>
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