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1000 Titel
  • Active Inflammatory and Chronic Structural Damages of Sacroiliac Joint in Patients With Radiographic Axial Spondyloarthritis and Non-Radiographic Axial Spondyloarthritis
1000 Autor/in
  1. Tu, Liudan |
  2. Lin, Churong |
  3. Xie, Ya |
  4. Wang, Xiaohong |
  5. Wei, Qiujing |
  6. Zhang, Yanli |
  7. Gu, Jieruo |
1000 Verlag
  • Frontiers Media S.A.
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-27
1000 Erschienen in
1000 Quellenangabe
  • 12:700260
1000 Copyrightjahr
  • 2021
1000 Embargo
  • 2022-01-29
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2021.700260 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353186/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Abstract/Summary
  • <jats:sec><jats:title>Objective</jats:title><jats:p>Evaluate the MRI evidence of active inflammatory and chronic structural damages in radiographic axial spondyloarthritis (r-axSpA) and non-radiographic axial spondyloarthritis (nr-axSpA).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A retrospective review of 253 patients who underwent sacroiliac joint (SIJ) MRI between June 2014 and December 2019 was performed. MRI images including short tau inversion recovery scan and T1-weighted spin echo scans were assessed using the Spondyloarthritis Research Consortium of Canada (SPARCC) score and SPARCC MRI SIJ structural score by two independent readers.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Higher mean score of inflammatory (SPARCC) was seen in r-axSpA patients when compared with nr-axSpA patients (8.08 <jats:italic>vs</jats:italic> 4.37, <jats:italic>P</jats:italic>&amp;lt;0.05). Frequencies of MRI structural lesions in r-axSpA patients and nr-axSpA patients were as follows: erosion (65.84 <jats:italic>vs</jats:italic> 88.23%, <jats:italic>P</jats:italic>=0.002), backfill (33.17 <jats:italic>vs</jats:italic> 13.73%, <jats:italic>P</jats:italic>&amp;lt;0.001), fat metaplasia (79.21 <jats:italic>vs</jats:italic> 60.78%, <jats:italic>P</jats:italic>=0.01), and ankylosis (37.13 <jats:italic>vs</jats:italic> 1.96%, <jats:italic>P</jats:italic>&amp;lt;0.001). Patients with r-axSpA had a higher mean score for fat metaplasia (8.93 <jats:italic>vs</jats:italic> 4.06, <jats:italic>P</jats:italic>=0.0003) and ankylosis (4.49 <jats:italic>vs</jats:italic> 0.04, <jats:italic>P</jats:italic>&amp;lt;0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>More active inflammatory and chronic structural damages except for erosion were seen in r-axSpA patients than nr-axSpA patients, while higher percentage of nr-axSpA patients presented with erosion in MRI.</jats:p></jats:sec>
1000 Sacherschließung
lokal Female [MeSH]
lokal Immunology
lokal axial spondyloarthritis
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Sacroiliac Joint/pathology [MeSH]
lokal ankylosing spondylitis
lokal Retrospective Studies [MeSH]
lokal Middle Aged [MeSH]
lokal Non-Radiographic Axial Spondyloarthritis/pathology [MeSH]
lokal structural damage
lokal MRI
lokal Axial Spondyloarthritis/pathology [MeSH]
lokal Magnetic Resonance Imaging [MeSH]
lokal Male [MeSH]
lokal Inflammation/pathology [MeSH]
lokal inflammation
1000 Liste der Beteiligten
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