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10.1186_s40463-023-00687-w.pdf 1,40MB
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1000 Titel
  • Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review
1000 Autor/in
  1. Newman, Matthew |
  2. Nguyen, Thomas |
  3. McHugh, Tobial |
  4. Reddy, Kesava |
  5. Sommer, Doron Dov |
1000 Verlag
  • SAGE Publications
1000 Erscheinungsjahr 2023
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2023-12-01
1000 Erschienen in
1000 Quellenangabe
  • 52(1)
1000 Copyrightjahr
  • 2023
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40463-023-00687-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10731762/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:sec><jats:title>Background</jats:title><jats:p> Juvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1–6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns. </jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p> The purpose of this systematic review is to identify cases of early-onset JNA (EOJNA), (defined as age &lt; 10 years) in the literature and to examine the disease characteristics and treatments used in this patient group. A case of a 7 year old boy with EOJNA at our institution is also described and presented. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We searched Embase, Cochrane database and MEDLINE from 1996 to February 2021 for studies that reported cases of EOJNA. Relevant clinico-demographic data, disease severity and treatment outcomes were recorded and analyzed using descriptive statistics. We compared our findings with reported means for JNA in all ages. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> We identified 29 studies containing a total of 34 cases of EOJNA. The vast majority (31/34) of patients were males and the mean age of diagnosis was 8.15 years old. The most common presenting symptoms were nasal obstruction (65.2%) and epistaxis (60.9%). Patients were most commonly Radkowski stage II (39.4%) and III (39.4%). Primary treatment modalities included open surgery (66.7%), endoscopic surgery (24.2%), and radiotherapy (9.1%). Recurrence was evident in 30%. Radkowski stage and type of treatment did not differ significantly within the EOJNA group ( p = 0.440 and p = 0.659, respectively). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> This systematic review suggests that rare cases of EOJNA have distinct disease characteristics. Patients in this cohort appeared to have more advanced disease and higher recurrence rates when compared with reported averages. We hope that this review prompts increased clinical awareness of this potentially more aggressive subtype of JNA. As more cases of EOJNA are reported, a more powered statistical analysis of this cohort would be feasible. </jats:p></jats:sec>
1000 Sacherschließung
lokal Adolescent [MeSH]
lokal Female [MeSH]
lokal Epistaxis [MeSH]
lokal Recurrence
lokal Early-onset
lokal Adult [MeSH]
lokal Humans [MeSH]
lokal Treatment Outcome [MeSH]
lokal Retrospective Studies [MeSH]
lokal Skull base
lokal Nasal Obstruction/etiology [MeSH]
lokal Angiofibroma/diagnosis [MeSH]
lokal Male [MeSH]
lokal Neoplasm
lokal Angiofibroma/surgery [MeSH]
lokal Young Adult [MeSH]
lokal Nasopharyngeal Neoplasms/diagnosis [MeSH]
lokal Review
lokal Endoscopic
lokal Juvenile nasopharyngeal angiofibroma
lokal Radkowski stage
lokal Child [MeSH]
lokal Pediatric
lokal Nasopharyngeal Neoplasms/surgery [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TmV3bWFuLCBNYXR0aGV3|https://orcid.org/0000-0002-6563-996X|https://frl.publisso.de/adhoc/uri/TWNIdWdoLCBUb2JpYWw=|https://frl.publisso.de/adhoc/uri/UmVkZHksIEtlc2F2YQ==|https://frl.publisso.de/adhoc/uri/U29tbWVyLCBEb3JvbiBEb3Y=
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  1. Early-Onset Juvenile Nasopharyngeal Angiofibroma (JNA): A Systematic Review
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1000 Erstellt am 2024-05-21T10:07:00.348+0200
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