Download
10.1186_s40463-022-00559-9.pdf 1,04MB
WeightNameValue
1000 Titel
  • Mutational status may supersede tumor size in predicting the presence of aggressive pathologic features in well differentiated thyroid cancer
1000 Autor/in
  1. Semsar-Kazerooni, Koorosh |
  2. Morand, Grégoire B. |
  3. Payne, Alexandra E. |
  4. da Silva, Sabrina D. |
  5. Forest, Véronique-Isabelle |
  6. Hier, Michael P. |
  7. Pusztaszeri, Marc P. |
  8. Tamilia, Michael |
  9. Payne, Richard J. |
1000 Verlag
  • SAGE Publications
1000 Erscheinungsjahr 2022
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-01-01
1000 Erschienen in
1000 Quellenangabe
  • 51(1):9
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40463-022-00559-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895819/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>In clinical practice, thyroid tumor size plays a critical role in the staging of thyroid malignancies and in the selection of nodules that should undergo ultrasound-guided fine-needle aspiration. Thyroid tumor size is influenced by the elapsed time since the beginning of oncogenesis and by the presence of somatic mutations driving growth, such as <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> mutations, associated with aggressive phenotypes, and <jats:italic>RAS-</jats:italic>like mutations, associated with more indolent behavior. Although large nodules are often considered to be more alarming, the true impact of tumor size on prognosis remains controversial. The aim of this study was to assess the relationship between mutational status, tumor size and aggressiveness, with emphasis on <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> and <jats:italic>RAS</jats:italic>-like mutations.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>We conducted a multicentric retrospective chart review in Montréal, Canada, of all patients who underwent thyroid surgery between January 2016 and December 2020, with well-differentiated thyroid cancer on final pathology, and who had undergone molecular testing revealing the presence of <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> mutations or <jats:italic>RAS</jats:italic>-like mutations (<jats:italic>NRAS</jats:italic>, <jats:italic>HRAS</jats:italic> or <jats:italic>KRAS</jats:italic>).</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We included 214 cases. There were 117 (54.7%) cases of <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> and 97 (45.3%) cases of <jats:italic>RAS</jats:italic>-like mutations. The <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> group was statistically associated with a smaller mean tumor size when compared with the <jats:italic>RAS</jats:italic> group of 1.55 cm and 2.04 cm, respectively. In a multivariate model, tumors with <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> mutations were also more likely to display aggressive pathological features, including extra-thyroidal extension, lymph node metastasis, columnar cell features, tall cell histology, or hobnail histology (OR 26.69; 95% CI 11.15–70.81). In contrast, tumor size was not associated with pathologic aggressive features on multivariate analysis (OR 0.81; 95% CI 0.54–1.22).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study demonstrates that thyroid tumors expressing <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> mutations correlate with aggressive pathologic features more than tumors expressing <jats:italic>RAS</jats:italic>-like mutations. When comparing tumors with <jats:italic>BRAF</jats:italic><jats:sup><jats:italic>V600E</jats:italic></jats:sup> and <jats:italic>RAS</jats:italic>-like mutations, the former were found to be smaller. As a result of this finding, this study suggests that molecular alterations may better predict aggressive pathologic features than the size of the tumor.</jats:p> </jats:sec><jats:sec> <jats:title>Graphical abstract</jats:title> </jats:sec>
1000 Sacherschließung
lokal Mutation [MeSH]
lokal Molecular diagnostic techniques
lokal Mutation
lokal Proto-Oncogene Proteins B-raf/genetics [MeSH]
lokal Thyroid neoplasms
lokal Humans [MeSH]
lokal Retrospective Studies [MeSH]
lokal Thyroid nodule
lokal Thyroid Neoplasms/genetics [MeSH]
lokal DNA Mutational Analysis [MeSH]
lokal Thyroid Neoplasms/pathology [MeSH]
lokal Thyroid Cancer, Papillary/pathology [MeSH]
lokal Thyroid Neoplasms/surgery [MeSH]
lokal Original Research Article
lokal Ultrasonography
lokal Proto-oncogene proteins p21(ras)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1486-0314|https://frl.publisso.de/adhoc/uri/TW9yYW5kLCBHcsOpZ29pcmUgQi4=|https://frl.publisso.de/adhoc/uri/UGF5bmUsIEFsZXhhbmRyYSBFLg==|https://frl.publisso.de/adhoc/uri/ZGEgU2lsdmEsIFNhYnJpbmEgRC4=|https://frl.publisso.de/adhoc/uri/Rm9yZXN0LCBWw6lyb25pcXVlLUlzYWJlbGxl|https://frl.publisso.de/adhoc/uri/SGllciwgTWljaGFlbCBQLg==|https://frl.publisso.de/adhoc/uri/UHVzenRhc3plcmksIE1hcmMgUC4=|https://frl.publisso.de/adhoc/uri/VGFtaWxpYSwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/UGF5bmUsIFJpY2hhcmQgSi4=
1000 Hinweis
  • DeepGreen-ID: 5e689fdf210b4c0baac17be16ae472e3 ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
1000 Label
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6477900.rdf
1000 Erstellt am 2024-05-21T11:39:51.730+0200
1000 Erstellt von 322
1000 beschreibt frl:6477900
1000 Zuletzt bearbeitet 2024-05-22T09:24:10.551+0200
1000 Objekt bearb. Wed May 22 09:24:10 CEST 2024
1000 Vgl. frl:6477900
1000 Oai Id
  1. oai:frl.publisso.de:frl:6477900 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source