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Abstract/Summary
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<jats:sec><jats:title>Background</jats:title><jats:p> Squamous cell carcinoma of the external auditory canal (EACSCC) is an uncommon tumor and responsible for no more than 0.2% of all the head and neck malignancies. Although there is remarkable research evidence exhibiting that high-risk human papillomavirus (HPV) accounts for considerable head and neck malignancies, its role in the pathogenesis of EACSCC is yet to be determined. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We evaluated 16 patients with EACSCC treated at our department. We employed PCR to assay for high-risk subtypes of HPV. Two pathologists reviewed the histopathological staining via hematoxylin and eosin along with immunohistochemical staining of p16<jats:sup>INK4a</jats:sup> and Ki-67. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Detection of HPV DNA was done via PCR in 3 (18.75%) patients, and 8 (50%) positive (+) cases were determined via p16<jats:sup>INK4a</jats:sup> immunostaining. Besides, 3 (37.5%) individuals were HPV positive as per p16<jats:sup>INK4a</jats:sup> PCR results. In addition, all of the p16<jats:sup>INK4a</jats:sup>-positive specimens were diagnosed as moderately differentiated carcinomas. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Expression of Ki-67 was related to HPV status. This is the first report implicating high-risk HPV in squamous cell carcinoma of the external auditory canal. However, p16<jats:sup>INK4a</jats:sup> immunostaining is a suspectable approach for diagnosing HPV for EACSCC. In addition, HPV might enhance an elevated proliferation rate in EACSCC, illustrated via expression of Ki-67. </jats:p></jats:sec><jats:sec><jats:title>Graphical Abstract</jats:title><jats:p> </jats:p></jats:sec>
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Hinweis
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DeepGreen-ID: 171bb2eafe7d4c99a96d99c91df1de7d ; metadata provieded by: DeepGreen (https://www.oa-deepgreen.de/api/v1/), LIVIVO search scope life sciences (http://z3950.zbmed.de:6210/livivo), Crossref Unified Resource API (https://api.crossref.org/swagger-ui/index.html), to.science.api (https://frl.publisso.de/), ZDB JSON-API (beta) (https://zeitschriftendatenbank.de/api/), lobid - Dateninfrastruktur für Bibliotheken (https://lobid.org/resources/search)
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