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10.1186_s40463-020-00410-z.pdf 500,53KB
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1000 Titel
  • The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: A case control study
1000 Autor/in
  1. Chang, Ning-Chia |
  2. Yang, Hua-Ling |
  3. Dai, Chia-Yen |
  4. Lin, Wen-Yi |
  5. Wang, Hsun-Mo |
  6. Chien, Chen-Yu |
  7. Ho, Kuen-Yao |
1000 Verlag
  • SAGE Publications
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-01-01
1000 Erschienen in
1000 Quellenangabe
  • 49(1):16
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40463-020-00410-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137511/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan.</jats:p> </jats:sec><jats:sec> <jats:title>Method</jats:title> <jats:p>Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>These findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.</jats:p> </jats:sec>
1000 Sacherschließung
lokal Audiometry, Pure-Tone [MeSH]
lokal Female [MeSH]
lokal Single nucleotide polymorphism
lokal Aged [MeSH]
lokal Asian Continental Ancestry Group/genetics [MeSH]
lokal Polymorphism, Single Nucleotide [MeSH]
lokal Humans [MeSH]
lokal Age-related hearing impairment
lokal Aging [MeSH]
lokal Receptors, Interleukin-1 Type I/genetics [MeSH]
lokal Taiwan [MeSH]
lokal Interleukin-1 receptor
lokal Male [MeSH]
lokal Receptors, Interleukin-1 Type II/genetics [MeSH]
lokal Case-Control Studies [MeSH]
lokal Genotype [MeSH]
lokal Original Research Article
lokal Hearing Loss/genetics [MeSH]
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